Modeling human diseases in C. elegans

Summary

We use the model organism Caernorhabditis elegans for modeling human diseases. Our group has investigated genes involved in RNA processing that are altered in rare diseases or cancer. Thanks to CRISPR technologies, we are moving towards personalized medicine by mimicking human mutations in C. elegans. Moreover, we are taking advantages of the C. elegans feasibility for CRISPR genome editing to develop more efficient and versatile methodologies to edit genetic loci.

34 Publications

Strategic lines

Selected Publications

-Saura Esteller J, Sanchez Vera I, Nunez Vazquez S, Jabalquinto Carrasco J, Cosialls AM, Mendive Tapia L, Kukhtar D, Martinez Bueno MD, Lavilla R, Ceron J, Artal Sanz M, Pons G, Iglesias Serret D, Gil J. Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells. Apoptosis. 2021;26(1-2):83-95. doi:10.1007/s10495-020-01651-z. IF:4,68.

-Vicencio J, Ceron J. A Living Organism in your CRISPR Toolbox: Caenorhabditis elegans Is a Rapid and Efficient Model for Developing CRISPR-Cas Technologies. CRISPR J. 2021;4(1):32-42. doi:10.1089/crispr.2020.0103. IF:6,07.

Selected Projects

- MCI21008. Development of CRISPR-Cas technologies in C. elegans to investigate human pathogenic mutations and other gene variants, and to create rare disease models. (PID2020-114986RB-I00). MINISTERIO DE CIENCIA E INNOVACIÓN (MICINN). 2021-2024. IP: CERON MADRIGAL,JULIAN.

- 20PSJ012. Towards the first tumor in the genetic model Caenorhabditis elegans. (IDEAS20078CERÓ). AECC. 2020-2022. IP: CERON MADRIGAL,JULIAN.

- 20MEC001. Optimización de CRISPR en C. elegans: nuevos reporteros y reemplazo de genes. (PRX19/00425). MINISTERIO DE EDUCACIÓN Y FORMACIÓN PROFESIONAL. 2020-2021. IP: CERON MADRIGAL,JULIAN.

- 18AGA001. AJUTS PER CONTRACTAR PERSONAL INVESTIGADOR NOVELL (FI-DGR 2018). (2020 FI_B2 00160). 2018-2021. IP: CERON MADRIGAL, JULIAN.

- 18PSJ004. Genome editing as prognostic and therapeutic tool in human diseases. 2018-2021. IP: CERON MADRIGAL,JULIAN.