Modeling human diseases in C. elegans
The processing mechanisms of RNA are highly preserved between yeast and human beings and are necessary to transfer DNA information to protein synthesis, a process which is frequently altered in human diseases. The group uses the C. elegans multicellular organism and its powerful genetic and genomic tools to clarify which steps of RNA metabolism are affected in various diseases. In C. elegans, the group also studies why the interruption of gene functions can contribute to genome instability, cell death and uncontrolled cell division. As such, it strives to understand the mechanisms which give sensitivity and resistance to anticancer therapies.