Tumour angiogenesis

Summary

Our research group at the ProCURE Program (Catalan Institute of Oncology) and OncoBell Program (IDIBELL) is focused on determining the consequences of adaptation and resistance to anti-angiogenic cancer therapy. For that we use translational research in murine models of cancer, particularly Kindey Cancer PDOX models and NeuroEndocrine transgenic models to study in vivo mechanisms of adaptation to anti-angiogenics, and validate our findings using clinical samples from our hospital and collaborating institutions.
Our scientific achievements have been published in prestigious journals in the field of cancer research with numerous "preview", "highlight" or commentary articles in high impact scientific journals. Furthermore, we have an important international position in the field of antitumor therapies and angiogenic resistance mechanisms.

144 Publications

Strategic lines

Selected Publications

Fullana,B;Morales,S;Petit,A;Alay,A;Verdaguer,H;Climent,F;Navarro Perez,V et al, Neoadjuvant sunitinib plus exemestane in post-menopausal women with hormone receptor-positive/HER2-negative early-stage breast cancer (SUT_EXE-08): a phase I/II trial., Sci Rep, 2024;14(1):23626-23626, doi:10.1038/s41598-024-72152-1
Mireles,M;Jiménez Valerio,G;Morales Dalmau,J;Johansson,JD;Martínez Lozano,M;Vidal Rosas,EE;Navarro Pérez,V et al, Prediction of the response to antiangiogenic sunitinib therapy by non-invasive hybrid diffuse optics in renal cell carcinoma, Biomed Opt Express, 2024;15(10):5773-5789, doi:10.1364/BOE.532052
Crugeiras,J;Calls,A;Contreras,E;Alemany,M;Navarro,X;Yuste,VJ;Casanovas,O et al, Oxygen matters: Unraveling the role of oxygen in the neuronal response to cisplatin, J Peripher Nerv Syst, 2024;29(4):528-536, doi:10.1111/jns.12659
Ligero M, Hernando J, Delgado E, Garcia-Ruiz A, Merino-Casabiel X, Ibrahim T, Fazio N, Lopez C, Teulé A, Valle JW, Tafuto S, Custodio A, Reed N, Raderer M, Grande E, Garcia-Carbonero R, Jimenez-Fonseca P, Garcia-Alvarez A, Escobar M, Casanovas O, Capdevila J & Perez-Lopez R., Radiomics and outcome prediction to antiangiogenic treatment in advanced gastroenteropancreatic neuroendocrine tumours: findings from the phase II TALENT trial., British Journal of Cancer Reports, 2023, doi:10.1038/s44276-023-00010-0
Peix,F;Casanovas,O, Promalignant effects of antiangiogenics in the tumor microenvironment., Semin. Cancer Biol., 2022;86(Pt 3):199-206, doi:10.1016/j.semcancer.2022.03.003

Selected Projects

CPP2023-010718. Opening a New Era in Hepatocellular Carcinoma by a Novel Blood Biomarker for Individual Selection of Treatment (PersonalHCC). Ministerio de Ciencia e Innovación. Budget: 514.874€. 2024-2027. PI: CASANOVAS CASANOVAS, ORIOL.
PID2022-142386OB-I00. Disección de los mecanismos de Plaquetas y genes de Coagulación en la metástasis del Cancer de Riñón. Ministerio de Ciencia e Innovación. Budget: 436.758€. 2024-2028. PI: CASANOVAS CASANOVAS, ORIOL.
2021 SGR 01289. Interacció Tumor Estroma i Resistència Terapèutica – ITERT. AGENCIA GESTIO D’AJUTS UNIV. I RECERCA. Budget: 40.000€. 2022-2025. PI: CASANOVAS CASANOVAS, ORIOL.
DTS21/00163. Angiotheragnostics: Desarrollo de un nuevo tratamiento con su biomarcador de selección de pacientes para pacientes con cáncer colorectal avanzado. Instituto de Salud Carlos III (ISCIII). Budget: 176.000€. 2022-2024. PI: CASANOVAS CASANOVAS, ORIOL.
PID2019-107557RB-I00. Targeteando la Coagulación en la formación de metástasis en cáncer renal. Ministerio de Ciencia e Innovación. Budget: 145.200€. 2020-2024. PI: CASANOVAS CASANOVAS, ORIOL.
CI-008/19. ANÁLISIS DE MUESTRAS DEL ESTUDIO TALENT QUE GESTIONA GETNE. GETNE. Budget: 49.334€. 2019- . PI: CASANOVAS CASANOVAS, ORIOL.

Technology transfer

More Information

2015 Proof of Concept (PoC) grant from the European Research Council – Oriol Casanovas.

Mapping the pathogenesis of vascular malformations
IP: Graupera Garcia-Mila, Mariona (Project Leader)
Partners: Centro Nacional de Investigaciones Cardiovasculares-CNIC (Dr. R. Benedito), Hospital Santa Creu Sant Pau (Dra. E. Baselga) i Sant Joan de Déu (Dr. J. Mora)
Call: Health Research 2018 Call for proposals, expediente: HR18-00120
Funding Entity: Fundació “la Caixa”