Cell signalling and bone biology

Summary

Our goal is to understand the signaling pathways involved in cell communication. We focus on how alterations in signaling can alter metabolism, pathophysiology, and bone regeneration, with the aim of finding new therapies by modification of these pathways.
This group is an association of two independent teams at the University of Barcelona; the group led by Dr. Jose Luis Rosa focusing on “Ubiquitin ligases in health and disease”, and the laboratory of “Signaling and bone biology” led by Dr. Francesc Ventura.

212 Publications

Strategic lines

1.- Ubiquitination and cell signalling (José Luis Rosa):

Study of the signalling pathways involved in proliferation and differentiation regulated by ubiquitin ligases.

Physiological and pathological relevance of HERC ubiquitin ligases.

2.- Bone pathophysiology, bone regeneration and osteointegration (Francesc Ventura):

Bone pathophysiology, bone regeneration and osseointegration: Metabolic reprogramming in bone development.

Pathophysiology and therapeutic alternatives for the treatment of progressive ossifying fibrodysplasia (FOP).

Stem cells and scaffold generation as a therapeutic strategy for bone tissue engineering.

Selected Publications

Pimenta Lopes,C;Sánchez Diego,C;Deber,A;Egea Cortés,A;Valer,JA;Alcalá,A;Méndez Lucas,A et al, Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss., Mol. Ther., 2023;31(8):2507-2523, doi:10.1016/j.ymthe.2023.04.022
Pedrazza,L;Martinez,A;Sanchez Diego,C;Valer,JA;Pimenta Lopes,C;Sala Gaston,J;Szpak,M et al, HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling, Cell Death Dis., 2023;14(1):17-17, doi:10.1038/s41419-023-05549-x
José Antonio ValerAlexandre DeberMarius WitsCarolina Pimenta-LopesMarie-José GoumansJosé Luis RosaGonzalo Sánchez-DuffhuesFrancesc Ventura, PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification, eLife,2023, 12:RP91779. , doi: 10.7554/eLife.91779.1
Villanueva Carmona,T;Cedo,L;Madeira,A;Ceperuelo Mallafre,V;Rodriguez Pena,MM;Nunez Roa,C;Maymo Masip,E et al, SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression, Cell Metab., 2023;35(4):doi:10.1016/j.cmet.2023.03.004
Sanz Serrano,D;Sanchez Diego,C;Mercade,M;Ventura,F, Dental Stem Cells SV40, a new cell line developed in vitro from human stem cells of the apical papilla, Int. Endod. J., 2022;56(4):502-513, doi:10.1111/iej.13887