The Neurometabolic Diseases group strives to establish the pathophysiology of neurometabolic diseases to develop rational treatment strategies. To achieve this, it uses transcriptomics, proteomics, metabolomics and lipidomics, taking an integrative systems-biology approach. Our work has been mainly focussed on clarifying the molecular bases of X-linked adrenoleukodystrophy, particularly towards oxidative stress and pathways of mitochondrial dysfunction. Furthermore, the group takes a comparative genomic approach to study the evolutionary origin of peroxisomes and their related metabolic pathways, focussing on lipid metabolism. The derived knowledge could contribute to unravelling the role of this barely studied organelle in ageing and neurodegenerative diseases.