New target Therapy for Triple Negative Breast Cancer
Problema a solucionar
Breast cancer is the most common malignancy among females in the Western world, resulting in approximately half a million deaths annually, mainly due to metastatic disease. TNBC, which lacks estrogen receptor, progesterone receptor and HER2 expression, accounts for approximately 15–20% of all breast cancers. Despite its sensitivity to chemotherapy, TNBC remains a clinical challenge because of a high rate of relapse, a propensity to form visceral metastasis and the lack of targeted therapies. Lung cancer, with over 1.5 million deaths yearly has become the leading cause of cancer-related mortality worldwide. One of the main unmet needs in TNBC treatment is the need for more effective treatment options that provide substantial improvement in progression-free survival (PFS) and overall survival (OS).
The most important benefits of this new therapy are based on Medical need to treat TNBC/NSCLC patients
The economic burden for public health systems generated by standard non-selected and ineffective cancer treatment.
These new RANK inhibitory molecules will improve the current treatments with less side effects.
Estat de la tecnologia
The RANK signaling pathway has emerged as a new target in breast and NSCLC. In mouse models have already been performed showing that Rank pathway promotes mammary tumorigenesis and lung metastasis In silico drug design models will be performed in order to select and validate the NCE (new chemical entity)
This new target therapy proof of concept is based on the innovative idea of generating novel small molecules targeting RANK for the treatment of triple negative breast cancer (TNBC) and non-small cell adenocarcinomas (NSCLC), aggressive subtypes where no targeted therapies are available. Despite encouraging evidences in mouse models, anti-RANKL drugs (the antibody denosumab) have failed to show a benefit preventing recurrence in clinical breast cancer. Our value proposition: New strategy to inhibit RANK pathway for the treatment of TNBC and NSCLC
RANK is expressed in breast and lung tumors, particularly in tumors from the TNBC and NSCLC subtype, where no targeted therapies are available. Taking into a count that RANK expression associates with prognosis and RANK receptor can signal in the absence of RANKL, our unique insight to solve this problem is a New strategy to inhibit RANK pathway for the treatment of TNBC and NSCLC.
Eva González-Suárez (IDIBELL)
Technology Readiness Level
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