Physiology and pathology of the functional relationship between glia and neurons

Summary

Chloride is the most abundant anion in organisms. The plasma-membrane chloride channels of the CLC and LRRC8 family are important for various physiological functions, such as regulation of nerve- and muscle-cell excitability, both in terms of cell-volume regulation and transepithelial transport. The physiological roles of various chloride channels are illustrated in human hereditary diseases caused by mutations in the genes or auxiliary subunits which regulate their functions. This group’s aim is therefore to try to understand chloride-channel regulation in order to provide therapeutic solutions to patients affected by this. The group has a multidisciplinary approach, applying imaging methods, electrophysiology and biochemistry in mice and red-pepper models.

73

Publications

rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue
Estevez Povedano, Raul

Estevez Povedano, Raul

Principal investigators

Estevez Povedano, Raul

Estevez Povedano, Raul

Team

Group leaders
  • Estevez Povedano, Raul
Postdoctoral investigators (R2)
Predoctoral researchers (R1)
Scroll to Top