#IDIBELLseminars: Microtubule nucleation: how making new microtubules supports brain development.
Institute for Research in Biomedicine
Sala de Graus, aulari UB Bellvitge
Microtubules mediate a range of essential cellular processes such as mitotic spindle assemble and segregation of chromosomes during cell division, intracellular transport, or cell polarization. All of these functions are crucial during brain development where mitotic and non-mitotic roles of microtubules need to be tightly coordinated. However, whereas we have a fairly good understanding of microtubule network organization in cultured cell lines, how this is achieved during neural development remains largely unknown. I will discuss our recent progress in identifying molecular players and mechanisms in neural progenitors and in neurons that allow assembly and remodeling of microtubule arrays suited to support both proliferation and neuronal differentiation.
Hosted by Artur Llobet, Cellular and Molecular Neurobiology Group
2000: PhD in Biology, University of Heidelberg, Germany
2001-2003: Postdoc, Max Planck Institute of Biochemistry, Martinsried, Germany (Laboratory of Stefan Jentsch)
Work on protein folding and degradation
2003-2007: Postdoc, Stanford University, Stanford, USA
(Laboratory of Tim Stearns)
Work on microtubule organization
2008-present: Group leader at IRB Barcelona, studying the molecular mechanisms underlying the organization of the microtubule cytoskeleton and how defects are linked to disease.