#IDIBELLfellows: Gemma Gonfaus / Lucia del Carmen Gonzalez Alcocer

Role of the NADPH oxidase NOX4 in the regulation of Endoplasmic Reticulum (ES) stress in liver tumor cells
Gemma Gonfaus – TGF-beta and cancer group

Psychosocial and Sociodemographic Profiles of Breast Cancer Patients
Lucia del Carmen Gonzalez Alcocer – Psycho-oncology and digital health (PSODIG) group
Introduction: Receiving a Breast Cancer diagnosis is frequently perceived as a threatening experience (ref). Patients commonly experience anxiety, depression, distress, and post-traumatic stress. These symptoms often persist throughout their treatment and survivorship journey. Psychological treatments for those symptoms have demonstrated efficacy in early-stage cancer patients, but there are still many challenges related to access, dosage, and responsiveness. ICOnnecta’t is a stepped digital psychosocial health program designed and created to address these needs.
Aims: to identify the presence of recently diagnosed BC patient subgroups classified according to psychosocial, sociodemographic and clinical variables. Methods: This study follows an additional analysis of a larger multicentre randomized controlled trial (RCT) that evaluated the effectiveness of ICOnnecta`t.
Results: revealed the existence of three groups: Cluster 1 (Early stages and minimal distress, 61.7%) having least psychosocial impairment, Cluster 2 (Advanced Stages and Moderate Distress, 16.8%) included patients in advanced cancer stages and moderate psychological impairment. Cluster 3 (Distress and Growth in Early Stages, 21.6%) had the highest post-traumatic stress and psychological distress, but also showed significant post-traumatic growth. Emotional distress and cancer stage were the main discriminators between clusters, while sociodemographic variables showed limited relevance.