Stem Cell Aging
Somatic stem cells have the ability to regenerate tissues over time. This capacity declines with age, disrupting tissue maintenance. Understanding how stem cells age and identifying intervention strategies to maintain stem cell regenerative capacity will lead to new therapeutic approaches for maintaining our health as we age. Our lab uses mouse models to explore the biology of stem cell function and regeneration and to identify mechanisms of age-related stem cell dysfunction. Our focus is on epigenetic alterations that can be pharmacologically targeted and on the interactions between stem cells and their niche. Interventions that promote stem cell health are likely to provide new avenues to treat or prevent a wide range of age-related diseases. Coupling fundamental insight into stem cell biology to the exploration of such intervention strategies is going to help for the identification of new and promising therapeutic approaches.