Hematopoietic Stem Cell Biology And Leukemogenesis

Summary

Hematopoietic stem cells (HSCs) are considered the base of adult hematopoiesis. Currently, most of these hematological disorders are curable by HSC transplantation. However, the limited availability of optimally human matched donor remains a challenge, especially for individuals of non-Caucasian background or mixed ethnicity. Human pluripotent stem cells (PSCs), including embryonic stem cells (hESCs) and induced PSCs (hiPSCs), can differentiate in vitro into various hematopoietic cell type and could represent an ideal source of customized HSCs for clinical application. Furthermore, HSCs derived from patient-iPSCs not only represent an invaluable hematological disease modeling but might provide a cell-based platform for therapeutic screening. The production of engrafting HSCs from human PSCs will depend on the accurate recapitulation of embryonic hematopoiesis.

23

Publications

Hematopoietic-Stem-Cell-Biology-And-Leukemogenesis
Alessandra-Giorgetti

Giorgetti, Alessandra

Principal investigators

Alessandra-Giorgetti

Giorgetti, Alessandra

OTHER LINKS

Twitter

ORCID

Google Scholar

Team

Group leaders
  • Giorgetti, Alessandra
Predoctoral researchers (R1)
Research technicians
Scroll to Top