Cellular and molecular basis of sensory disorders

Summary

The group undertakes the challenges of treating sensory disorders and preserving sensory functions during ageing, through the study of original animal models in the vestibular system and retina. The group develops models which enable it to obtain therapeutically relevant information on these highly complex sensory systems through the use of first-line methodologies, such as super-resolution fluorescence microscopy, RNA-seq and proteomics.

149 Publications

208-basescelmoltrastsensorials-jllorens-def

Strategic lines

Study of cellular and molecular mechanisms of vestibular dysfunction using chronic toxicity models and in vitro models
Rodent models to assess vestibular function
Zebrafish models to study hair cell degeneration
Causes of vestibular loss in vestibular schwannoma patients
Photoreceptor cell physiology
Molecular and cellular basis of light adaptation
Phosphoproteome of the dark/light retina
Retinal metabolism
Polarized ciliary trafficking in photoreceptor cells
Mouse models of inherited retinal dystrophies and testing of new therapeutic approaches

Selected Publications

Maroto,AF;Borrajo,M;Prades,S;Callejo,À;Amilibia,E;Pérez Grau,M;Roca Ribas,F et al, The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans., Arch. Toxicol., 2023;97(7):1943-1961, doi:10.1007/s00204-023-03518-z
Greguske,EA;Maroto,AF;Borrajo,M;Palou,A;Gut,M;Esteve Codina,A;Barrallo Gimeno,A et al, Decreased expression of synaptic genes in the vestibular ganglion of rodents following subchronic ototoxic stress., Neurobiol. Dis., 2023;182106134-106134, doi:10.1016/j.nbd.2023.106134
Schenberg,L;Palou,A;Simon,F;Bonnard,T;Barton,C;Fricker,D;Tagliabue,M et al, Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells., Elife, 2023;12doi:10.7554/eLife.88819,
Sires,A;Pazo Gonzalez,M;Lopez Soriano,J;Mendez,A;de la Rosa,EJ;de la Villa,P;Comella,JX et al, The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina, Cells, 2023;12(3):doi:10.3390/cells12030487
Cerdá,P;Castillo,SD;Aguilera,C;Iriarte,A;Rocamora,JL;Larrinaga,AM;Viñals,F et al, New genetic drivers in hemorrhagic hereditary telangiectasia, Eur. J. Intern. Med., 2023;11999-108, doi:10.1016/j.ejim.2023.08.024,

Selected Projects

PUB22015. Aplicació de noves tecnologies moleculars en el diagnòstic genètic de les distròfies hereditàries de retina. Hospital Universitario de Bellvitge. Budget: 20.000€. 2022-2025. PI: Cobos Martín, Estefanía.
2022-222-1. RETROSPECTIVE CHART REVIEW STUDY COMBINED WITH CROSS-SECTIONAL PATIENT AND CAREGIVER SURVEYS TO DOCUMENT AND DESCRIBE THE DISEASE-RELATED CLINICAL, INDIVIDUAL, SOCIO-DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH X-LINKED RETINITIS PIGMENTOSA (XLRP) AND THE IMPACT OF XLRP ON PATIENTS AND THEIR CAREGIVERS.
(EXPLORE XLRP 2 ). Budget: 7.850€. 2022- . PI: Cobos Martín, Estefanía.

More Information

Identification of nitriles as a new family of compounds with vestibular toxicity.
Basic animal models for the ablation of capillary cells in the vestibular system of mice.
Identification of synaptic decoupling and extrusion of capillary cells as the main events in chronic vestibular toxicity.
Characterisation of the role of GCAP proteins in light responses.
Identification of GCAP2 as a mediator of light damage, involved in the pathophysiology of “light” genetic disorders.