Cellular and molecular basis of sensory disorders

Summary

The group undertakes the challenges of treating sensory disorders and preserving sensory functions during ageing, through the study of original animal models in the vestibular system and retina. The group develops models which enable it to obtain therapeutically relevant information on these highly complex sensory systems through the use of first-line methodologies, such as super-resolution fluorescence microscopy, RNA-seq and proteomics.

149 Publications

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Strategic lines

Study of cellular and molecular mechanisms of vestibular dysfunction using chronic toxicity models
Rodent models to assess vestibular function
Zebrafish models to study hair cell degeneration
Causes of vestibular loss in vestibular schwannoma patients
Photoreceptor cell physiology Molecular and cellular basis of light adaptation
Phosphoproteome of the dark/light retina
Retinal metabolism Polarized ciliary trafficking in photoreceptor cells
Mouse models of inherited retinal dystrophies

Selected Publications

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

Plana-Bonamaiso, Anna; Lopez-Begines, Santiago; Fernandez-Justel, David; Junza, Alexandra; Soler-Tapia, Ariadna; Andilla, Jordi; Loza-Alvarez, Pablo; Luis Rosa, Jose; Miralles, Esther; Casals, Isidre; Yanes, Oscar; de la Villa, Pedro; Buey, Ruben M.; Mendez, Ana

ELIFE. 2020, doi: 10.7554/eLife.56418

GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress.

Plana-Bonamaisó A, López-Begines S, Andilla J, Fidalgo MJ, Loza-Alvarez P, Estanyol JM, Villa P, Méndez A.

CELL DEATH & DISEASE. 2020, doi: 10.1038/s41419-020-2255-0

Assessment of cochlear toxicity in response to chronic 3,3'-iminodipropionitrile in mice reveals early and reversible functional loss that precedes overt histopathology

Plana-Bonamaisó A, López-Begines S, Fernández-Justel D, Junza A, Soler-Tapia A, Andilla J, Loza-Alvarez P, Rosa JL, Miralles E, Casals I, Greguske EA, Llorens J, Pyott SJ

ARCHIVES OF TOXICOLOGY. 2021, doi: 10.1007/s00204-020-02962-5

Calyx junction dismantlement and synaptic uncoupling precede hair cell extrusion in the vestibular sensory epithelium during sub-chronic 3,3′-iminodipropionitrile ototoxicity in the mouse.

Greguske E., Carreres-Pons M., Cutillas B., Boadas-Vaello P., Llorens J.

ARCHIVES OF TOXICOLOGY. 2019, doi: 10.1007/s00204-018-2339-0

Quantitative Assessment of Anti-Gravity Reflexes to Evaluate Vestibular Dysfunction in Rats

Martins-Lopes V., Bellmunt A., Greguske E.A., Maroto A.F., Boadas-Vaello P., Llorens J.

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY. 2019, doi: 10.1007/s10162-019-00730-6

Selected Projects

Molecular responses of the vestibular system to chronic ototoxicity: identification of mechanisms and development of models for in vivo analysis

Llorens Baucels, Jordi / Barrallo Gimeno, Alejandro (Principal investigator (PI))

Funder:

Agencia Estatal de Investigación

01/01/2019 - 31/12/2020

Busqueda de dianas terapeuticas para las distrofias hereditarias de retina: caracterizacion de un nuevo complejo multienzimatico central en la fisiologia de fotorreceptores

Mendez Zunzunegui, Ana (Principal investigator (PI))

Funder:

Agencia Estatal de Investigación

01/01/2017 - 31/12/2020

More Information

Identification of nitriles as a new family of compounds with vestibular toxicity.
Basic animal models for the ablation of capillary cells in the vestibular system of mice.
Identification of synaptic decoupling and extrusion of capillary cells as the main events in chronic vestibular toxicity.
Characterisation of the role of GCAP proteins in light responses.
Identification of GCAP2 as a mediator of light damage, involved in the pathophysiology of “light” genetic disorders.