Cellular and molecular basis of sensory disorders

Study of cellular and molecular mechanisms of vestibular dysfunction using chronic toxicity models
Rodent models to assess vestibular function
Zebrafish models to study hair cell degeneration
Comprehensive study of dark/light photoreceptor cell physiology
Phosphoproteome of the dark/light retina
Guanine metabolism in photoreceptor cells
Mouse models of inherited retinal dystrophies

Calyx junction dismantlement and synaptic uncoupling precede hair cell extrusion in the vestibular sensory epithelium during sub-chronic 3,3′-iminodipropionitrile ototoxicity in the mouse.

Greguske E., Carreres-Pons M., Cutillas B., Boadas-Vaello P., Llorens J.

ARCHIVES OF TOXICOLOGY. (ISSN: 03405761) 2019

Quantitative Assessment of Anti-Gravity Reflexes to Evaluate Vestibular Dysfunction in Rats

Martins-Lopes V., Bellmunt A., Greguske E.A., Maroto A.F., Boadas-Vaello P., Llorens J.

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY (ISSN: 1438-7573) 2019

Morphological and functional correlates of vestibular synaptic deafferentation and repair in a mouse model of acute-onset vertigo

Cassell, R; Bordiga, P; Carcaud, J; Simone, F; Beraneck, M; Le Gallo, A; Benoit, A; Bouet, V; Philoxene, B; Besnard, S; Watabe, I; Pericat, D; Hautefort, C; Assie, A; Tonetto, A; Dyhrfjeld-Johnsen, J; Llorens, J; Tighilet, B; Chabbert, C

DISEASE MODELS & MECHANISMS (ISSN: 1754-8403) 2019

GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress.

Plana-Bonamaisó A, López-Begines S, Andilla J, Fidalgo MJ, Loza-Alvarez P, Estanyol JM, Villa P, Méndez A.

CELL DEATH & DISEASE 2020

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions.

Plana-Bonamaisó A, López-Begines S, Fernández-Justel D, Junza A, Soler-Tapia A, Andilla J, Loza-Alvarez P, Rosa JL, Miralles E, Casals I, Yanes O, de la Villa P, Buey RM, Méndez A.

ELIFE 2020

Molecular responses of the vestibular system to chronic ototoxicity: identification of mechanisms and development of models for in vivo analysis

Llorens Baucels, Jordi / Barrallo Gimeno, Alejandro (Principal investigator (PI))

Funder:

• Agencia Estatal de Investigación

01/01/2019 - 31/12/2020

Busqueda de dianas terapeuticas para las distrofias hereditarias de retina: caracterizacion de un nuevo complejo multienzimatico central en la fisiologia de fotorreceptores

Mendez Zunzunegui, Ana (Principal investigator (PI))

Funder:

• Agencia Estatal de Investigación

01/01/2017 - 31/12/2020

Identification of nitriles as a new family of compounds with vestibular toxicity.
Basic animal models for the ablation of capillary cells in the vestibular system of mice.
Identification of synaptic decoupling and extrusion of capillary cells as the main events in chronic vestibular toxicity.
Characterisation of the role of GCAP proteins in light responses.
Identification of GCAP2 as a mediator of light damage, involved in the pathophysiology of “light” genetic disorders.