Cellular and molecular basis of sensory disorders

Summary

The group undertakes the challenges of treating sensory disorders and preserving sensory functions during ageing, through the study of original animal models in the vestibular system and retina. The group develops models which enable it to obtain therapeutically relevant information on these highly complex sensory systems through the use of first-line methodologies, such as super-resolution fluorescence microscopy, RNA-seq and proteomics.

149 Publications

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Strategic lines

Study of cellular and molecular mechanisms of vestibular dysfunction using chronic toxicity models and in vitro models
Rodent models to assess vestibular function
Zebrafish models to study hair cell degeneration
Causes of vestibular loss in vestibular schwannoma patients
Photoreceptor cell physiology
Molecular and cellular basis of light adaptation
Phosphoproteome of the dark/light retina
Retinal metabolism
Polarized ciliary trafficking in photoreceptor cells
Mouse models of inherited retinal dystrophies and testing of new therapeutic approaches

Selected Publications

Barrallo Gimeno A, Llorens J. Hair cell toxicology: With the help of a little fish. Front. Cell. Dev. Biol. 2022;10doi:10.3389/fcell.2022.1085225.

Garg G, Finger PT, Kivelä TT, Simpson ER, Gallie BL, Saakyan S, Amiryan AG, Valskiy V, Chin KJ, Semenova E, Seregard S, Filì M, Wilson M, Haik B, Caminal JM, Catala Mora J, Gutiérrez C, Pelayes DE, Folgar AM, Jager MJ, Dogrusöz M, Luyten GPM, Singh AD, Suzuki S, AJCC Ophthalmic Oncology Task F. Patients presenting with metastases: stage IV uveal melanoma, an international study. Br J Ophthalmol. 2022;106(4):510-517. doi:10.1136/bjophthalmol-2020-317949.

Caminal JM, Lorenzo D, Gutierrez C, Slocker A, Piulats JM, Cobos E, Garcia Bru P, Morwani R, Santamaria JF, Arias L. Local Resection in Choroidal Melanoma: A Review. J. Clin. Med. 2022;11(23):doi:10.3390/jcm11237156.

Garcia Tornel A, Millan M, Rubiera M, Bustamante A, Requena M, Dorado L, Olivé Gadea M, Jiménez X, Soto A, Querol M, Hernández Pérez M, Gomis M, Cardona P, Urra X, Purroy F, Silva Y, Ustrell X, Esteve P, Salvat Plana M, Gallofré M, Molina C, Dávalos A, Jovin T, Abilleira S, Ribo M, Pérez de la Ossa N, RACECAT Trial I. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas. Stroke. 2022;doi:10.1161/STROKEAHA.122.040768.

Gabrielle PH, Nguyen V, Arnould L, Viola F, Zarranz Ventura J, Barthelmes D, Creuzot Garcher C, Gillies M, Fight Retinal Blindness! Study G. Incidence, Risk Factors, and Outcomes of Rhegmatogenous Retinal Detachment after Intravitreal Injections of Anti-VEGF for Retinal Diseases: Data from the Fight Retinal Blindness! Registry. Ophthalmol Retina. 2022;6(11):1044-1053. doi:10.1016/j.oret.2022.05.008.

Selected Projects

PUB22015. Aplicació de noves tecnologies moleculars en el diagnòstic genètic de les distròfies hereditàries de retina. Hospital Universitario de Bellvitge. Budget: 20000. 2022-2025. PI: Cobos Martín, Estefanía.

2022-222-1. RETROSPECTIVE CHART REVIEW STUDY COMBINED WITH CROSS-SECTIONAL PATIENT AND CAREGIVER SURVEYS TO DOCUMENT AND DESCRIBE THE DISEASE-RELATED CLINICAL, INDIVIDUAL, SOCIO-DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH X-LINKED RETINITIS PIGMENTOSA (XLRP) AND THE IMPACT OF XLRP ON PATIENTS AND THEIR CAREGIVERS.
(EXPLORE XLRP 2 ). Budget: 7850. 2022- . PI: Cobos Martín, Estefanía.

PCI2020-120681-2. Vestibular loss and spatial orientation. ERA-NET Neuron (Agencia Estatal de Investigación). Budget: 150000. 2021-2024. PI: Llorens Baucells, Jordi.

PID2021-124678OB-I00. New molecular mechanisms in chronic vestibular damage. Agencia Estatal de Investigación. Budget: 96800. 2022-2025. PI: Llorens Baucells, Jordi i Barrallo Gimeno, Alejandro.

PID2020-115431RB-I00. Retinal adaptation to light and pan-disease therapeutic targets in inherited blindness: IMPDH1 and energy metabolism. Agencia Estatal de Investigación. Budget: 120000. 2021-2024. PI: Méndez Zunzunegui, Ana.

202007-30-31. A patient centered research: awareness of patient needs, clinical phenotyping and molecular parthenogenesis in Neurofibromatosis type 2. Fundació La Marató de TV3. Budget: 142485,90. 2021-2024. PI: Llorens Baucells, Jordi.

More Information

Identification of nitriles as a new family of compounds with vestibular toxicity.
Basic animal models for the ablation of capillary cells in the vestibular system of mice.
Identification of synaptic decoupling and extrusion of capillary cells as the main events in chronic vestibular toxicity.
Characterisation of the role of GCAP proteins in light responses.
Identification of GCAP2 as a mediator of light damage, involved in the pathophysiology of “light” genetic disorders.