TGF-beta and cancer

Summary

The group consists of four principal investigators, whose lines of research have as a common link to advance in the knowledge of the molecular mechanisms that influence tumor cell plasticity and the tumor-stroma interactions. The group has a special interest on the role of transforming growth factor (TGF)-β in regulating these processes, as well as on deciphering the relevance of other signaling pathways, such as epidermal growth factor (EGF) or interferon (IFN) signaling. The research is mainly focused on liver, pancreatic and skin cancer, but additional models are also being worked in collaboration with other groups.

268 Publications

Strategic lines

Molecular mechanisms involved in tumour cell migration, plasticity, invasion and metastasis. Role of TGF-beta, EGF and IFN in these processes.
Exosomes and MicroRNAs as promoters of the metastatic niche: cross-talk with the TGF-beta pathway.
Role of the NADPH oxidase (NOX) family as mediator of TGF-beta effects. The TGF-beta/NOX4 axis as regulator of the cellular metabolism and redox balance.
Analysis of the tumor-stroma interaction in cancer initiation and progression.

Selected Publications

Penuelas Haro I, Espinosa Sotelo R, Crosas Molist E, Herranz Iturbide M, Caballero Diaz D, Alay A, Sole X, Ramos E, Serrano T, Martinez Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression. Hepatology. 2022;doi:10.1002/hep.32702.

Vaquero J, Pavy A, Gonzalez Sanchez E, Meredith M, Arbelaiz A, Fouassier L. Genetic alterations shaping tumor response to anti-EGFR therapies. Drug Resist Updat. 2022;64100863-100863. doi:10.1016/j.drup.2022.100863.

Espinet E, Klein L, Puré E, Singh SK. Mechanisms of PDAC subtype heterogeneity and therapy response. Trends Cancer. 2022;8(12):1060-1071. doi:10.1016/j.trecan.2022.08.005.

Vinyals A, Ferreres JR, Calbet Llopart N, Ramos R, Tell Martí G, Carrera C, Marcoval J, Puig S, Malvehy J, Puig Butille JA, Fabra À. Oncogenic properties via MAPK signaling of the SOX5-RAF1 fusion gene identified in a wild-type NRAS/BRAF giant congenital nevus. Pigment Cell Melanoma Res. 2022;35(4):450-460. doi:10.1111/pcmr.13044.

Goikoetxea Usandizaga N, Serrano Maciá M, Delgado TC, Simón J, Fernández Ramos D, Barriales D, Cornide ME, Jiménez M, Pérez Redondo M, Lachiondo Ortega S, Rodríguez Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero Díaz D, Alfano B, Bravo M, González Recio I, Mercado Gómez M, Gil Pitarch C, Mabe J, Gracia Sancho J, Abecia L, Lorenzo Ó, Martín Sanz P, Abrescia N, Sabio G, Rincón M, Anguita J, Miñambres E, Martín C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela Rey M, Martínez Chantar ML. Mitochondrial bioenergetics boost macrophages activation promoting liver regeneration in metabolically compromised animals. Hepatology. 2022;75(3):550-566. doi:10.1002/hep.32149.

Selected Projects

19MEC012. Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneración y cáncer hepáticos. Relación con la vía del TGF-beta. Ministerio de Ciencia e Innovación. Budget: 338800. 2019-2022. PI: Fabregat Romero, María Isabel.

AEC21009. Towards a precision medicine using TGF-ß inhibitors in hepatocellular carcinoma and cholangiocarcinoma. Asociación Española Contra el Cáncer (AECC). Budget: 299813,75. 2021-2024. PI: Fabregat Romero, María Isabel.

20MEC015. Diseccionando el papel terapéutico de la NADPH oxidasa NOX4 en colangiocarcinoma por medio de secuenciación masiva de RNA en célula única (NOX4CHOL). Ministerio de Ciencia e Innovación. Budget: 181500. 2020-2023. PI: Vaquero Rodríguez, Javier.

20MEC023. DESARROLLO PRECLÍNICO DE UN NUEVO ACTIVO MODULADOR DE LA FIBROSIS Y LA SENESCENCIA PARA EL TRATAMIENTO DE LA ENFERMEDAD DE HÍGADO GRASO NO-ALCOHÓLICO (HEPATOSEN). Ministerio de Ciencia e Innovación. Budget: 159287,29. 2020-2022. PI: Fabregat Romero, María Isabel.

21PSJ005. Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche. FUNDACIÓN RAMÓN ARECES. Budget: 112000. 2021-2024. PI: Fabregat Romero, María Isabel.

Technology transfer

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