TGF-beta and cancer
The group consists of two principal investigators (Àngels Fabra and Isabel Fabregat) who lead independent laboratories, but who came together a few years ago to work in close collaboration and become more competitive. The common link between the two is their interest in the transforming growth factor (TGF)-β, a cytokine with pleiotropic actions, the signalling of which is involved in human physiology and pathology. The group’s main aim is to establish whether the TGF-β pathway is a therapeutic target in liver fibrosis and cancer (IF Lab) and in cutaneous and uveal melanoma (AF Lab).
- Fabregat Romero, María Isabel