TGF-beta and cancer

Summary

The group consists of four principal investigators, whose lines of research have as a common link to advance in the knowledge of the molecular mechanisms that influence tumor cell plasticity and the tumor-stroma interactions. The group has a special interest on the role of transforming growth factor (TGF)-β in regulating these processes, as well as on deciphering the relevance of other signaling pathways, such as epidermal growth factor (EGF) or interferon (IFN) signaling. The research is mainly focused on liver, pancreatic and skin cancer, but additional models are also being worked in collaboration with other groups.

268 Publications

Strategic lines

Molecular mechanisms involved in tumour cell migration, plasticity, invasion and metastasis. Role of TGF-beta, EGF and IFN in these processes.
Exosomes and MicroRNAs as promoters of the metastatic niche: cross-talk with the TGF-beta pathway.
Role of the NADPH oxidase (NOX) family as mediator of TGF-beta effects. The TGF-beta/NOX4 axis as regulator of the cellular metabolism and redox balance.
Analysis of the tumor-stroma interaction in cancer initiation and progression.

Selected Publications

- Lobe C, Vallette M, Arbelaiz A, Gonzalez Sanchez E, Izquierdo L, Pellat A, Guedj N, Louis C, Paradis V, Banales JM, Coulouarn C, Housset C, Vaquero J*, Fouassier L. ZEB1 promotes cholangiocarcinoma progression through tumor dedifferentiation and tumor-stroma paracrine signaling. Hepatology. 2021;74(6):3194-3212. doi:10.1002/hep.32069. IF:17,43.

- NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice.
Herranz-Itúrbide M, López-Luque J, Gonzalez-Sanchez E, Caballero-Díaz D, Crosas-Molist E, Martín-Mur B, Gut M, Esteve-Codina A, Jaquet V, Jiang JX, Török NJ, Fabregat I*. Redox Biol. 2021 Apr;40:101841. doi: 10.1016/j.redox.2020.101841. Epub 2020 Dec 23.PMID: 33493901 . IF: 11.779

- Gonzalez Sanchez E*, El Mourabit H, Jager M, Clavel M, Moog S, Vaquero J, Ledent T, Cadoret A, Gautheron J, Fouassier L, Wendum D, Chignard N, Housset C. Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice. Biochim. Biophys. Acta-Mol. Basis Dis. 2021;1867(4):166067-166067. doi:10.1016/j.bbadis.2020.166067. IF:5,19.

- Soukupova J, Malfettone A, Bertran E, Hernandez Alvarez MI, Penuelas Haro I, Dituri F, Giannelli G, Zorzano A, Fabregat I*. Epithelial-Mesenchymal Transition (EMT) Induced by TGF-beta in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism. Int. J. Mol. Sci. 2021;22(11):doi:10.3390/ijms22115543. IF:5,92.

- Sabate Llobera A, Mestres Marti J, Reynes Llompart G, Llado L, Mils K, Serrano T, Cortes Romera M, Bertran E, Fabregat I, Ramos E. 2-[F-18]FDG PET/CT as a Predictor of Microvascular Invasion and High Histological Grade in Patients with Hepatocellular Carcinoma. Cancers. 2021;13(11):doi:10.3390/cancers13112554. IF:6,64.

Selected Projects

- 21PSJ005. Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche. . FUNDACIÓN RAMÓN ARECES. 2021-2024. IP:FABREGAT ROMERO,MARIA ISABEL.

- 20MEC015. Diseccionando el papel terapéutico de la NADPH oxidasa NOX4 en colangiocarcinoma por medio de secuenciación masiva de RNA en célula única (NOX4CHOL). (PID2019-108651RJ-I00). MINISTERIO DE CIENCIA E INNOVACIÓN (MICINN). 2020-2023. IP:Vaquero Rodríguez,JAVIER.

- 20MEC023. DESARROLLO PRECLÍNICO DE UN NUEVO ACTIVO MODULADOR DE LA FIBROSIS Y LA SENESCENCIA PARA EL TRATAMIENTO DE LA ENFERMEDAD DE HÍGADO GRASO NO-ALCOHÓLICO (HEPATOSEN). (RTC2019-007125-1). CIC BIOGUNE; FUNDACIO IDIBELL; INSTITUT RECERCA BIOMÉDICA DE BARCELONA; MINISTERIO DE CIENCIA E INNOVACIÓN (MICINN); SENOLYTIC THERAPEUTICS SL. 2020-2022. IP:FABREGAT ROMERO,MARIA ISABEL.

- 19MEC012. Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneración y cáncer hepáticos. Relación con la vía del TGF-beta. (RTI2018-094079-B-I00). MINISTERIO DE CIENCIA E INNOVACIÓN (MICINN). 2019-2022. IP:FABREGAT ROMERO,MARIA ISABEL.

- 19FIS026. Uveal Melanoma and liver metastasis: predictive use of molecular alterations and therapeutic opportunities. (PI18/01131). INSTITUTO DE SALUD CARLOS III. 2019-2022. IP:CAMINAL MITJANA, JOSE MARIA ; CO-IP: FABRA FRES, ÀNGELS.

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