TGF-beta and cancer

• Molecular mechanisms involved in tumour cell migration, plasticity, invasion and metastasis: the role of TGF-beta in these processes

• Exosomes and MicroRNAs as promoters of the metastatic niche: crossing with the TGF-beta pathway

• The role of the NADPH oxidase (NOX) family as mediator of TGF-beta effects during liver regeneration, fibrosis and cancer

• The role of the TGF-beta/NOX4 axis in the regulation of metabolism

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition.

López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Malfettone A, Caja L, Serrano T, Ramos E, Sanz-Moreno V, Fabregat I

CANCER LETTERS (ISSN: 0304-3835) 2019

Clathrin switches transforming growth factor-β role to pro-tumorigenic in liver cancer.

Caballero-Díaz D, Bertran E, Peñuelas-Haro I, Moreno-Càceres J, Malfettone A, López-Luque J, Addante A, Herrera B, Sánchez A, Alay A, Solé X, Serrano T, Ramos E, Fabregat I

JOURNAL OF HEPATOLOGY (ISSN: 0168-8278) 2020

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.

Crosas-Molist E, Bertran E, Rodriguez-Hernandez I, Herraiz C, Cantelli G, Fabra À, Sanz-Moreno V, Fabregat I

JONCOGENE (ISSN: 0950-9232) 2017

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.

López-Luque J, Caballero-Díaz D, Martinez-Palacián A, Roncero C, Moreno-Càceres J, García-Bravo M, Grueso E, Fernández A, Crosas-Molist E, García-Álvaro M, Addante A, Bertran E, Valverde AM, González-Rodríguez Á, Herrera B, Montoliu L, Serrano T, Segovia JC, Fernández M, Ramos E, Sánchez A, Fabregat I

HEPATOLOGY (ISSN: 0270-9139) 2016

AURKA Overexpression Is Driven by FOXM1 and MAPK/ERK Activation in Melanoma Cells Harboring BRAF or NRAS Mutations: Impact on Melanoma Prognosis and Therapy.

Puig-Butille JA, Vinyals A, Ferreres JR, Aguilera P, Cabré E, Tell-Martí G, Marcoval J, Mateo F, Palomero L, Badenas C, Piulats JM, Malvehy J, Pujana MA, Puig S, Fabra À

JOURNAL OF INVESTIGATIVE DERMATOLOGY (ISSN: 0022-202X) 2017

Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneración y cáncer hepáticos. Relación con la vía del TGF-beta.

Fabregat Romero, Isabel (Principal investigator (PI))

Funder:

• AEI - MINISTERIO DE CIENCIA E INNOVACIÓN

01/01/2019 - 31/12/2021

Diseccionado el papel terapéutico de la NADPH oxidasa NOX4 EN colangiocarcinoma mediante la secuenciación masiva de RNA en célula única (NOX4CHOL).

Javier Vaquero Rodríguez (Principal investigator (PI))

Funder:

• AEI - MINISTERIO DE CIENCIA E INNOVACIÓN

01/10/2020 - 30/09/2023

Desarrollo preclínico de un nuevo activo modulador de la fibrosis y la senescencia para el tratamiento de la enfermedad de hígado graso no-alcohólico (hepatosen)

Fabregat Romero, Isabel (Principal investigator (PI))

Funder:

• AEI - MINISTERIO DE CIENCIA E INNOVACIÓN

01/10/2020 - 31/12/2022

Vias de diseminación metastásica en distintos subtipos del melanoma maligno: nuevos biomarcadores tumorales y dianas terapéuticas

Fabra Fres, Angels (Principal investigator (PI))

Funder:

• ASOCIACION ESPAÑOLA CONTRA EL CANCER

01/01/2016 - 31/12/2020

Uveal melanoma and liver metastasis:predictive use of molecular alterations and therapeutic opportunities

Fabra Fres, Angels (Principal investigator (PI))

Funder:

• FIS-Instituto de Salud Carlos III

01/01/2019 - 31/12/2021

Coordination of the European consortium IT-LIVER (inhibition of TGF-β in liver diseases) - Marie Curie International Training Network (ITN) programme.
National projects (Pla Estatal, FIS), private foundations (Marató TV3 and AECC) and projects with pharmaceutical companies (Digna - Spain, 4SC AG-Germany)