Hereditary cancer

Summary

A multidisciplinary research group which has been working in a clinical setting for over 20 years (Hereditary Cancer Programme of the Catalan Institute of Oncology) by providing genetic counselling on cancer and molecular/genetic tests. The group’s research focusses on improving healthcare for patients with a personal or family history of cancer or when the molecular features of the tumors developed may be used to guide treatment decisions. This research group aims:
- to improve clinical and molecular diagnosis, genetic counselling, management and treatment of individuals and families with an inherited predisposition to develop cancer and those having developed cancer;
- to study the genomics and molecular biology of hereditary benign and malignant tumors
- to develop and implement novel approaches that will improve the management of these patients and families including diagnostic, prognostic and therapeutic applications
- to promote training, education, outreach to medical and scientific community, patients and society on hereditary cancer predisposition

1243

Publications

Strategic lines

Improvement of molecular identification in hereditary cancer (Conxi Lázaro)
Personalising the risk of cancer in carriers (Marta Pineda, Gabriel Capellá)
Molecular mechanisms of new genes responsible for predisposition to hereditary cancer (Laura Valle, Marta Pineda, Gabriel Capellá, Bárbara Rivera)
Personalised risk assessment in patients with hereditary cancer without mutations in known cancer predisposing genes (Laura Valle, Conxi Lázaro)
Clinical and molecular characterisation of new hereditary cancer syndromes (Laura Valle, Bárbara Rivera)
Development of specific therapies in carriers of germline mutations by using experimental personalised models (Conxi Lázaro, Joan Brunet)
Development of a new bioethics framework for genetic studies in hereditary cancer (Gabriel Capellá, Joan Brunet)
Cost-effectiveness analysis of molecular diagnosis in hereditary cancer (Gabriel Capellá)
Development of research resources for patients, health care providers and reserachers interested in rare ovarian tumors (Bárbara Rivera, Joan Brunet).

Selected Publications

TP53, a gene for colorectal cancer predisposition in the absence of Li-Fraumeni-associated phenotypes

Terradas M, Mur P, Belhadj S, Woodward ER, Burghel GJ, Munoz-Torres PM, Quintana I, Navarro M, Brunet J, Lazaro C, Pineda M, Moreno V, Capella G, Evans DGR, Valle L

Gut 19,819. 2020, doi: 10.1136/gutjnl-2020-321825

Role of POLE and POLD1 in familial cancer

Mur, Pilar; Garcia-Mulero, Sandra; del Valle, Jesus; Magraner-Pardo, Lorena; Vidal, August; Pineda, Marta; Cinnirella, Giacomo; Martin-Ramos, Edgar; Pons, Tirso; Lopez-Doriga, Adriana; Belhadj, Sami; Feliubadalo, Lidia; Munoz-Torres, Pau M.; Navarro, Matilde; Grau, Elia; Darder, Esther; Llort, Gemma; Sanz, Judit; Ramon y Cajal, Teresa; Balmana, Judith; Brunet, Joan; Moreno, Victor; Piulats, Josep M.; Matias-Guiu, Xavier; Sanz-Pamplona, Rebeca; Aligue, Rosa; Capella, Gabriel; Lazaro, Conxi; Valle, Laura

GENETICS IN MEDICINE. 2020, doi: 10.1038/s41436-020-0922-2

ERCC3, a new ovarian cancer susceptibility gene?

Stradella, Agostina; del Valle, Jesus; Rofes, Paula; Vargas-Parra, Gardenia; Salinas, Monica; Gonzalez, Sara; Montes, Eva; Lopez-Doriga, Adriana; Gomez, Carolina; de Cid, Rafael; Darder, Esther; Teule, Alex; Solanes, Ares; Munte, Elisabet; Capella, Gabriel; Pineda, Marta; Feliubadalo, Lidia; Brunet, Joan; Lazaro, Conxi

EUROPEAN JOURNAL OF CANCER. 2020, doi: 10.1016/j.ejca.2020.09.023

Use of patient derived orthotopic xenograft models for real-time therapy guidance in a pediatric sporadic malignant peripheral nerve sheath tumor

Fernandez-Rodriguez, Juana; Morales La Madrid, Andres; Gel, Bernat; Castaneda Heredia, Alicia; Salvador, Hector; Martinez-Iniesta, Maria; Moutinho, Catia; Morata, Jordi; Heyn, Holger; Blanco, Ignacio; Creus-Bachiller, Edgar; Capella, Gabriel; Farre, Lourdes; Vidal, August; Soldado, Francisco; Krauel, Lucas; Sunol, Mariona; Serra, Eduard; Villanueva, Alberto; Lazaro, Conxi

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY. 2020, doi: 10.1177/1758835920929579

Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals

Damaso, Estela; Gonzalez-Acosta, Maribel; Vargas-Parra, Gardenia; Navarro, Matilde; Balmana, Judith; Ramon y Cajal, Teresa; Tuset, Noemi; Thompson, Bryony A.; Marin, Fatima; Fernandez, Anna; Gomez, Carolina; Velasco, Angela; Solanes, Ares; Iglesias, Silvia; Urgel, Gisela; Lopez, Consol; del Valle, Jesus; Campos, Olga; Santacana, Maria; Matias-Guiu, Xavier; Lazaro, Conxi; Valle, Laura; Brunet, Joan; Pineda, Marta; Capella, Gabriel

CANCERS. 2020, doi: 10.3390/cancers12071799

Selected Projects

Modelando el precancer en la deficiencia reparadora de apareamientos erróneos germinal para un seguimiento personalizado basado en la respuesta immune

Capellá Munar, Gabriel & Pineda Riu, Marta(Principal investigators (PI))

Funder:

MINISTERIO EDUCACION I CIENCIA

2020-2024

Postdoctoral Junior Leader - INCOMING

Capellá Munar, Gabriel (Principal investigator (PI))

Funder:

Fundació "La Caixa"

2019-2022

Mecanismos no convencionales de inactivación génica en cáncer colorrectal hereditario

Valle Velasco, Laura (Principal investigator (PI))

Funder:

MINISTERIO DE EDUCACION Y CIENCIA

2016-2020

Tackling current challenges in the genetic diagnosis of hereditary cancer through integrative analysis of molecular, clinical and population data

Lazaro Garcia, Conxi (Principal investigator (PI))

Funder:

FIS-Instituto de Salud Carlos III

2020-2022

Caracterización Clínica y molecular de los tumores des estroma de los cordones sexuales de ovario

Rivera Polo, Barbara (Principal investigator (PI))

Funder:

FIS-Instituto de Salud Carlos III

2021-2023

Role of immune system inborn errors as determinants of the COVID-19 severity in hospitalized patients

Lazaro Garcia, Conxi (Principal investigator (PI))
Funder:

Fundació La Marató de TV3

2021-

Technology transfer

Polymorphisms associated with developing colorectal cancer, methods of detection and uses thereof

de la Chapelle, Albert (Autor o Coautor); Tanner, Stefan M. (Autor o Coautor); Valle Velasco, Laura (Autor o Coautor); Pasche, Boris (Autor o Coautor)

VCN Biosciences: Gabriel Capellá is Vice-chair of the Scientific Committee

Capellá Munar, Gabriel (Inventores/autores/obtentores)

Método de diagnóstico de cáncer colorectal. ESP20083127

Azuara Garcia, Daniel (Inventores/autores/obtentores)

Método de diagnóstico de cáncer colorectal. ESP20083127

Capellá Munar, Gabriel (Inventores/autores/obtentores)

Polyhydroxylated compounds as fatty acid synthase (FASN) inhibidors

Brunet Vidal, Joan Maria (Inventores/autores/obtentores)

See full list

More Information

Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):

Desarrollo de estrategias terapéuticas personalizadas para los tumores malignos de las vainas de los nervios periféricos: modelos in vivo y farmacogenómica

PI13/00285. 01/2014-06/2017. 95.500 €. IP: Concepción Lázaro García.

Establecimiento de una plataforma de ensayos terapéuticos personalizados in vitro e in vivo para los tumores malignos de las vainas de los nervios periféricos (MPNST) e Identificación de agentes terapéuticos personalizados para estos tumores hasta llegar a nivel preclínico. Se prevee que el análisis integrativo de los datos tanto farmacogenómicos constitucionales como genómicos, juntamente con los datos de respuesta a los diferentes tratamientos in vitro e in vivo, ha de permitir disponer de una mejor capacidad predictiva de respuesta utilizando tratamientos personalizados en nuevos casos de MPNST.

Desarrollo de un sistema no invasivo para el cribado de cáncer colorrectal basado en marcadores bacterianos en heces

PI: Capellá Munar, Gabriel
Convocatoria Retos Colaboración, expediente: RTC-2016-5017-1
Coordinador: GOODGUT SOCIETAT LIMITADA
Ministerio de Ciencia, Innovación y Universidades, perteneciente a la Agencia Estatal de Investigación (AEI).

Cofinanciado por el Fondo Europeo de Desarrollo Regional. FEDER, una manera de hacer Europa. Promover el desarrollo tecnológico, la innovación y una investigación de calidad).