Infections and cancer

Summary

The Infections and Cancer group focusses on the fight between viruses and hosts, from an evolutionary perspective: the antiviral mechanisms which animals have developed and the antiviral strategies which have contributed to virus selection. It researches the connection between infection and cancer, as exemplified by the human papilloma virus (HPV).

925 Publications

Strategic lines

Human papilloma virus (HPV) and genital cancer.
HPV and cancer of the oesophagus, oral cavity, skin, vagina, vulva, penis and anus.
Hepatotropic viruses (hepatitis B and C virus – HBV, HCV) and cancer of the liver.
Trials on HPV vaccination and intervention studies on cancer prevention.
Infectious aetiology of malignant lymphomas.
WHO/ICO HPV and Cervical Cancer Information Centre.
Development of logistics instruments for coordination and diffusion of information regarding viruses and cancer.
Screening and prevention of genital cancer.
Evaluation of virus detection technologies.
Financial modelling and evaluation of cancer prevention measures.

Selected Publications

Mehanna,H;Taberna,M;von Buchwald,C;Tous,S;Brooks,J;Mena,M;Morey,F et al, Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis, Lancet Oncol., 2023;24(3):239-251, doi:10.1016/S1470-2045(23)00013-X
Bruni,L;Albero,G;Rowley,J;Alemany,L;Arbyn,M;Giuliano,AR;Markowitz,LE et al, Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis, Lancet Glob. Health, 2023;11(9):1345-1362, doi:10.1016/S2214-109X(23)00305-4
Costas,L;Onieva,I;Pelegrina,B;Marin,F;Carmona,A;López Querol,M;Frias Gomez,J et al, Evaluation of Somatic Mutations in Urine Samples as a Noninvasive Method for the Detection and Molecular Classification of Endometrial Cancer, Clin. Cancer Res., 2023;29(18):3681-3690, doi:10.1158/1078-0432.CCR-23-0367
Pelegrina,B;Paytubi,S;Marin,F;Martinez,JM;Carmona,A;Frias Gomez,J;Peremiquel Trillas,P et al, Evaluation of somatic mutations in cervicovaginal samples as a non-invasive method for the detection and molecular classification of endometrial cancer, EBioMedicine, 2023;94104716-104716, doi:10.1016/j.ebiom.2023.104716
Frias Gomez,J;Alemany,L;Benavente,Y;Clarke,MA;de Francisco,J;De Vivo,I;Du,M et al, Night shift work, sleep duration and endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2)., Sleep Med Rev, 2023;72101848-101848, doi:10.1016/j.smrv.2023.101848

Selected Projects

CEE21039. PERCH: PartnERship to Contrast HPV. COMISSIÓ EUROPEA. Budget: 409.468,03€. 2022-2025. PI: Brotons Agulló, Maria.
20CEE006. RISCC: RISK-BASED SCREENING FOR CERVICAL CANCER. COMISSIÓ EUROPEA. Budget: 378.125€. 2020-2024. PI: Bosch José, Francesc Xavier.
19CEE002. HEADSpAcE: Translational studies of HEAD and neck cancer in South America and Europe. COMISSIÓ EUROPEA. Budget: 249.985€. 2019-2024. PI: Alemany Vilches, Maria Eulalia.
19ACL260. ENSAYO CLÍNICO EN FASE 3, INTERNACIONAL, MULTICÉNTRICO, ALEATORIZADO, DOBLE CIEGO Y CONTROLADO CON PLACEBO PARA ESTUDIAR LA EFICACIA, LA INMUNOGENICIDAD Y LA SEGURIDAD DE LA VACUNA 9VVPH, UNA VACUNA POLIVALENTE DE PARTÍCULAS VIROIDES L1, EN LA PREVENCIÓN DE LA INFECCIÓN BUCAL PERSISTENTE POR LOS TIPOS 16, 18, 31, 33, 45, 52 O 58 DEL VPH EN VARONES ADULTOS DE 20 A 45 AÑOS DE EDAD. MERCK SHARP & DOHME ESPAÑA S.A. Budget: 224.455€. 2020- . PI: Alemany Vilches, Maria Eulalia.
MCI22005. WOMEC ADVANCED : NUEVAS APROXIMACIONES PARA EL DIAGNÓSTICO DE CÁNCER DE ENDOMETRIO. Ministerio de Ciencia e Innovación. Budget: 194.288€. 2022-2025. PI: Costas Caudet, Laura.