Diagnostic algorithm for the detection of coronary artery disease mediated by blood RNA biomarkers.

Functional tests to demonstratethe presence of ischemia have limited feasibility in patients with reduced mobility and require hospital infrastructure and the expertise of a technician and cardiologist for implementation and interpretation.
Tests such as stress electrocardiogram (ECGs) have limited diagnostic accuracy and imaging-based functional tests are complex to perform and require experienced personnel. Other noninvasive techniques, such as computed tomography angiography (CTA), are much more accurate, but are expensive, and involve exposing the patient to ionizing radiation and contrast media associated with nephrotoxicity. The alternative for a definitive diagnosis is coronary angiography, but this is an invasive technique and can be associated with potentially serious complications.