#IDIBELLseminars: Developing the next generation of GE mouse models for investigation of thoracic cancers
Daniel Murphy
University of Glasgow
07/03/2025
13:00-14:00
Sala d’Actes Pau Viladiu
Abstract
Genetically engineered mouse models are increasingly used as avatars for the diseases they model, yielding mechanistic insight that is often inaccesible from analysis of patient-derived samples, as well as providing platforms for pre-clinical evaluation of new therapeutic strategies. GEMMs are however a work in progress and continuous refinement is needed to better recapitulate aspects of human cancers. I will discuss our attempts to improve mouse models of lung cáncer and mesothelioma, along with new genetic tolos currently in development to address additional gaps in the ability to fathfully recapitulate processes at work in cancer progression
Hosted by Cristina Muñoz-Pinedo – Preclinical and experimental research in thoracic tumors (PReTT) group
Short Bio
PhD from Uni Virginia, 2000
Postdoc at UCSF with Gerard Evan 2001-2008
Junior group leader Uni Würzburg, Germany 2008-2012
Senior Lecturer at Uni Glasgow & the Beatson Institute from 2012
Promoted to Professor 2020
Lab focus has evolved from general roles of MYC in cancer to specific focus on Mesothelioma & Lung Cancers