Segons l\u2019estudi, entre els pacients amb c\u00e0ncer rectal localment avan\u00e7at tractats de forma simult\u00e0nia amb quimioter\u00e0pia i radioter\u00e0pia, i cirurgia posterior, la desaparici\u00f3 completa de c\u00e8l\u00b7lules cancer\u00edgenes detectables (anomenada resposta patol\u00f2gica completa) despr\u00e9s de quimioradioter\u00e0pia i cirurgia est\u00e0 lligada a millors resultats a llarg termini. Aquests pacients sobreviuen m\u00e9s anys sense malaltia i tenen menys risc de met\u00e0stasi.<\/p>\n
Aquest fet, aparentment obvi, no havia pogut ser demostrat de forma clara fins ara i obre la porta a personalitzar els tractaments.<\/p>\n
Revisi\u00f3 d\u2019estudis<\/strong><\/p>\n En l\u2019estudi publicat a Lancet Oncology, els investigadors han revisat les dades de 17 estudis publicats en revistes cient\u00edfiques. Dels 3.105 pacients que havien participat en aquestes investigacions, 484 presentaven una resposta patol\u00f2gica completa despr\u00e9s de rebre radioter\u00e0pia preoperat\u00f2ria. Cinc anys despr\u00e9s, el 83,3% d\u2019aquests pacients continuava sense la malaltia, comparat amb el 65,6% dels afectats que no presentaven desaparici\u00f3 completa de les c\u00e8l\u00b7lules cancer\u00edgenes despr\u00e9s del tractament combinat.<\/p>\n Despr\u00e9s d\u2019analitzar els principals estudis publicats sobre el tema (realitzats molts d\u2019ells pels mateixos autors), els investigadors conclouen que la resposta patol\u00f2gica completa despr\u00e9s de rebre quimioter\u00e0pia o radioter\u00e0pia sembla ser un predictor de bon pron\u00f2stic en pacients amb c\u00e0ncer rectal localment avan\u00e7at.<\/p>\n El cap del grup de recerca de Patologia del Tub Digestiu de l\u2019IDIBELL i cap de secci\u00f3 d\u2019Aparell Digestiu de l\u2019Hospital Universitari de Bellvitge, Sebastiano Biondo, destaca que \u201cles conclusions de l\u2019estudi s\u00f3n cl\u00ednicament rellevants perqu\u00e8 permetrien estalviar la realitzaci\u00f3 de posteriors tractaments als pacients que responen b\u00e9 o intensificar-los si no responen\u201d. Fins i tot, explica el Dr. Biondo, \u201ces podria arribar a estalviar la cirurgia o fer-la menys invasiva si els pacients responen excepcionalment b\u00e9 al tractament combinat de radioter\u00e0pia i quimioter\u00e0pia.\u201d<\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> Revisi\u00f3 d\u2019estudis Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1,472],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 05:39:43","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9720"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9720"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9720\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nMonique Maas, Patty J Nelemans, Vincenzo Valentini, Prajnan Das, Claus R\u00f6del, Li-Jen Kuo, Felipe A Calvo, Julio Garc\u00eda-Aguilar, Rob Glynne-Jones, Karin Haustermans, Mohammed Mohiuddin, Salvatore Pucciarelli, William Small Jr, Javier Su\u00e1rez, George Theodoropoulos, Sebastiano Biondo*, Regina G H Beets-Tan, Geerard L Beets. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 2010; 11: 835\u201344.<\/p>\n","protected":false},"excerpt":{"rendered":"