Totes les c\u00e8l\u00b7lules del cos hum\u00e0 posseeixen un nucli central on es troba l’ADN (el nostre material gen\u00e8tic), un mitj\u00e0 aqu\u00f3s (citoplasma) on es produeixen les prote\u00efnes i tenen lloc els processos metab\u00f2lics, i una capa perif\u00e8rica que envolta tota la c\u00e8l\u00b7lula i li d\u00f3na forma (membrana plasm\u00e0tica). Existeix un tr\u00e0nsit continu de mol\u00e8cules entre aquests tres compartiments per a permetre el bon funcionament de la c\u00e8l\u00b7lula.<\/p>\n
El recent descobriment de l’equip dirigit per Manel Esteller, investigador ICREA, demostra que aquest tr\u00e0nsit s’interromp en les c\u00e8l\u00b7lules canceroses. El grup de petites mol\u00e8cules segrestades per la c\u00e8l\u00b7lula tumoral en el seu nucli s\u00f3n els anomenats microARNs, que no poden exercir la seva activitat normal d’inhibir el desenvolupament del c\u00e0ncer.<\/p>\n
\u201cEls tumors descrits\u201d, explica Manel Esteller, \u201cpresenten una mutaci\u00f3 en una prote\u00efna anomenada Exportina-5, la funci\u00f3 de la qual en una c\u00e8l\u00b7lula sana \u00e9s la de fer de taxista i transportar els microARNs des del nucli al citoplasma. Per\u00f2 en aquests c\u00e0ncers \u00e9s incapa\u00e7 de conduir-los fora del nucli, per la qual cosa es perd la seva capacitat protectora antitumoral\u201d.<\/p>\n
\u201cAquests resultats tenen conseq\u00fc\u00e8ncies per millorar el coneixement de les causes del c\u00e0ncer, per\u00f2 tamb\u00e9 per a possibles nous tractaments, perqu\u00e8 d’una banda es descobreix una nova via alterada en c\u00e0ncer que es desconeixia per complet i, per una altra, es disposa d’una nova diana molecular, cosa que hauria d’estimular la recerca de nous f\u00e0rmacs que ajudin a millorar el transport de mol\u00e8cules des del nucli\u201d.<\/p>\n
Refer\u00e8ncia de l\u2019article<\/strong> Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-08 06:37:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9718"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9718"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9718\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz Jr, Esteller M. A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells. Cancer Cell<\/p>\n","protected":false},"excerpt":{"rendered":"