La revista Nature Medicine publica aquesta setmana un estudi que descriu per primera vegada els mecanismes oncog\u00e8nics provocats per alteracions en el gen TLX1 en progenitors de c\u00e8l\u00b7lules T, en leuc\u00e8mies limfobl\u00e0stiques agudes. En concret, els investigadors han descobert alteracions cromos\u00f2miques i en el control de la mitosi. La investigaci\u00f3 ha comptat amb la participaci\u00f3 de Xavier Sol\u00e9, investigador de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de l’Institut Catal\u00e0 d’Oncologia (ICO).<\/p>\n
La leuc\u00e8mia limfobl\u00e1stica aguda de c\u00e8l\u00b7lules T \u00e9s un tumor hematol\u00f2gic agressiu que resulta de la transformaci\u00f3 maligna dels progenitors de les c\u00e8l\u00b7lules T. Aquest tipus de c\u00e0ncer suposa entre un 5% i un 10% de les leuc\u00e8mies infantils i fins al 30% de les adultes.<\/p>\n
Els investigadors han utilitzat diverses t\u00e8cniques d’an\u00e0lisis gen\u00e8tiques per estudiar la transformaci\u00f3 cel\u00b7lular indu\u00efda en models transg\u00e8nics experimentals de ratol\u00ed que expressaven de manera aberrant el gen TLX1.<\/p>\n
El 92% dels animals estudiats havien desenvolupat 52 setmanes despr\u00e9s una leuc\u00e8mia limfobl\u00e0stica aguda de c\u00e8l\u00b7lules T. Els tumors mostraven un alt nivell d’heterogene\u00eftat a nivell immuno-fenot\u00edpic.<\/p>\n
L’investigador de l’IDIBELL-ICO Xavier Sol\u00e9 ha col\u00b7laborat en l’an\u00e0lisi bioinform\u00e0tica. \u201cLes conclusions de la investigaci\u00f3 suposen un pas molt important en el coneixement dels mecanismes que es troben darrere de la sobreexpressi\u00f3 del gen TLX1 en les leuc\u00e8mies limfobl\u00e0sticas de c\u00e8l\u00b7lules T\u201d, explica l’investigador, encara que, conclou, \u201cara s’haurien de realitzar nous estudis abans d’aplicar aquests coneixements a la pr\u00e0ctica cl\u00ednica.\u201d <\/p>\n
Refer\u00e8ncia de l\u2019article<\/strong><\/p>\n Kim De Keersmaecker, Pedro J Real, Giusy Della Gatta, Teresa Palomero, Maria Luisa Sulis, Valeria Tosello, Pieter Van Vlierberghe, Kelly Barnes, Mireia Castillo, Xavier Sole*, Michael Hadler, Jack Lenz, Peter D Aplan, Michelle Kelliher, Barbara L Kee, Pier Paolo Pandolfi, Dietmar Kappes, Fotini Gounari, Howard Petrie, Joni Van der Meulen, Frank Speleman, Elisabeth Paietta, Janis Racevskis, Peter H Wiernik, Jacob M Rowe, Jean Soulier, David Avran, H\u00e9l\u00e8ne Cav\u00e9,Nicole Dastugue, Susana Raimondi, Jules P P Meijerink, Carlos Cordon-Cardo, Andrea Califano & Adolfo A Ferrando. The TLX1 oncogene drives aneuploidy in T cell transformation. Published online 24 October 2010; doi:10.1038\/nm.2246 <\/p>\n *Investigador IDIBELL<\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 22:59:49","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9715"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9715"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9715\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}