El treball, que es publica en el proper n\u00famero de la revista nord-americana Molecular Cancer Research, relaciona la caveolina-1, una prote\u00efna present en la membrana de les c\u00e8l\u00b7lules, amb la met\u00e0stasi del sarcoma d\u2019Ewing. Aquesta \u00e9s una malaltia molt agressiva, caracteritzada per met\u00e0stasis en fases molt inicials, que afecta fonamentalment nens i joves. Els \u00edndexs de curaci\u00f3 s\u00f3n molt baixos. <\/p>\n
L\u2019estudi demostra que la caveolina-1 t\u00e9 un paper fonamental en la regulaci\u00f3 de l\u2019habilitat de les c\u00e8l\u00b7lules tumorals per migrar, envair la matriu extracel\u00b7lular (el medi on es troben les c\u00e8l\u00b7lules) i colonitzar \u00f2rgans distants com ara els pulmons. Aquest \u00e9s el primer estudi que avalua el paper de la caveolina-1 en la met\u00e0stasi del sarcoma d\u2019Ewing<\/strong>. <\/p>\n El coordinador de l\u2019estudi, \u00d2scar Mart\u00ednez Tirado, cap del grup de recerca en Sarcomes de l\u2019IDIBELL, destaca que \u201cels resultats afegeixen rellev\u00e0ncia al paper determinant de la caveolina-1 en la biologia del sarcoma d\u2019Ewing.\u201d Mart\u00ednez Tirado afegeix que \u201cfins ara es coneixia la seva implicaci\u00f3 en l\u2019oncog\u00e8nesi [proc\u00e9s de transformaci\u00f3 maligna pr\u00e8via a l\u2019aparici\u00f3 d\u2019un tumor] i en la seva resist\u00e8ncia a la quimioter\u00e0pia i ara se suma la seva activitat en la met\u00e0stasi.\u201d Un estudi anterior publicat pel mateix grup de l\u2019IDIBELL va demostrar que la caveolina-1 \u00e9s la responsable de la resist\u00e8ncia a la quimioter\u00e0pia que desenvolupen les c\u00e8l\u00b7lules tumorals del sarcoma d\u2019Ewing. <\/p>\n Aquesta malaltia \u00e9s el segon c\u00e0ncer d\u2019ossos infantil m\u00e9s freq\u00fcent. Representa un dos o un tres per cent de tots els tumors infantils i t\u00e9 una incid\u00e8ncia anual de 0,6 casos per mili\u00f3 d\u2019habitants. El pron\u00f2stic de la malaltia \u00e9s greu. Sovint es dissemina a altres parts del cos, especialment a la medul\u00b7la \u00f2ssia, els pulmons, els ronyons, el cor i la gl\u00e0ndula suprarenal. <\/p>\n L\u2019estudi publicat a Molecular Cancer Research obre una via per desenvolupar nous f\u00e0rmacs per evitar la met\u00e0stasi en el sarcoma d\u2019Ewing<\/strong>. <\/p>\n L\u2019estudi ha comptat amb la participaci\u00f3 d\u2019investigadors de l\u2019Institut de Recerca Vall d\u2019Hebron, del St Jude Children’s Research Hospital de Memphis, Tennessee (Estats Units), i del Georgetown University Medical Center de Washington (Estats Units). <\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> <\/p>\n <\/strong> Miguel S\u00e1inz-Jaspeado*<\/strong>, Laura Lagares-Tena*<\/strong>, Jaime Lasheras*<\/strong>, Fariba Navid, Carlos Rodriguez-Galindo, Silvia Mateo-Lozano, Vicente Notario, Xavier Sanjuan*<\/strong>, Xavier Garcia del Muro*<\/strong>, \u00c0ngels Fabra* <\/strong>and Oscar M Tirado*<\/strong>. Caveolin-1 modulates the ability of Ewing\u2019s sarcoma to metastasize. Molecular Cancer Research. <\/p>\n *Investigadors IDIBELL<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" La caveolina-1 est\u00e0 implicada en la propagaci\u00f3 tumoral en el sarcoma d\u2019Ewing, un c\u00e0ncer ossi molt agressiu que afecta nens i joves Aquest \u00e9s el primer estudi que avalua el paper de la caveolina-1 en la met\u00e0stasi del sarcoma d\u2019Ewing obre una via per desenvolupar nous f\u00e0rmacs per evitar la met\u00e0stasi en el sarcoma d\u2019Ewing Refer\u00e8ncia de l\u2019article Miguel S\u00e1inz-Jaspeado* Laura Lagares-Tena* Jaime Lasheras* Xavier Sanjuan* Xavier Garcia del Muro* \u00c0ngels Fabra* Oscar M Tirado* *Investigadors IDIBELL<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9710","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 04:08:28","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9710"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9710\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}