{"id":9703,"date":"2010-12-22T00:00:00","date_gmt":"2010-12-21T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2010\/12\/22\/identifiquen-en-pacients-un-nou-gen-implicat-en-el-cancer-de-pulmo\/"},"modified":"2020-05-13T19:51:00","modified_gmt":"2020-05-13T17:51:00","slug":"identifiquen-en-pacients-un-nou-gen-implicat-en-el-cancer-de-pulmo","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2010\/12\/identifiquen-en-pacients-un-nou-gen-implicat-en-el-cancer-de-pulmo\/","title":{"rendered":"Identifiquen en pacients un nou gen implicat en el c\u00e0ncer de pulm\u00f3"},"content":{"rendered":"<p>Gr\u00e0cies a aquests aven\u00e7os, un estudi realitzat per investigadors del grup de Gens i C\u00e0ncer del Programa d\u2019Epigen\u00e8tica i Biologia del C\u00e0ncer de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) ha identificat per primer cop en teixit tumoral primari de malalts de c\u00e0ncer de pulm\u00f3 la mutaci\u00f3 del gen SMARCA4. En condicions normals, aquest gen, tamb\u00e9 conegut amb el nom BRG1, permet produir una prote\u00efna que frena el desenvolupament del c\u00e0ncer de pulm\u00f3. Investigacions pr\u00e8vies realitzades tamb\u00e9 pels mateixos investigadors de l\u2019IDIBELL havien detectat aquesta mutaci\u00f3 en cultius cel\u00b7lulars <em>in vitro<\/em>. L\u2019estudi, liderat per la investigadora Montse S\u00e1nchez-C\u00e9spedes, s\u2019acaba de publicar en l\u2019edici\u00f3 digital de la revista Human Mutation. <\/p>\n<p> Els investigadors han utilitzat una nova t\u00e8cnica de <em>screening<\/em> massiu que permet detectar mutacions de forma m\u00e9s precisa. Mentre que la t\u00e8cnica tradicional requereix que com a m\u00ednim un 10% de la mostra contingui c\u00e8l\u00b7lules alterades per poder-les identificar, el nou sistema \u00e9s capa\u00e7 de detectar-les amb un 2%. <\/p>\n<p> La mutaci\u00f3 en el gen SMARCA4 \u00e9s la quarta causa m\u00e9s freq\u00fcent de c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lula no petita, que suposa el 80% dels c\u00e0ncers de pulm\u00f3. <\/p>\n<p> L\u2019estudi s\u2019ha publicat en l\u2019edici\u00f3 digital de la revista Human Mutation. El primer signant de la investigaci\u00f3, Salvador Rodr\u00edguez-Nieto, destaca que la identificaci\u00f3 d\u2019aquest gen en mostres tumorals de pacients \u00e9s important per desenvolupar nous f\u00e0rmacs en el futur: \u201cla restauraci\u00f3 de la funci\u00f3 del gen alterat permet revertir el proc\u00e9s tumoral, cosa que el converteix en una diana terap\u00e8utica molt prometedora.\u201d <\/p>\n<p> El de pulm\u00f3 \u00e9s un dels c\u00e0ncers m\u00e9s freq\u00fcents al m\u00f3n. \u00c9s la primera causa de mort per c\u00e0ncer en els pa\u00efsos desenvolupats. La taxa de superviv\u00e8ncia dels afectats continua sent molt baixa perqu\u00e8 \u00e9s dif\u00edcil detectar-lo abans de disseminar-se a altres \u00f2rgans del cos. Nou de cada deu c\u00e0ncers de pulm\u00f3 estan causats pel tabac. <\/p>\n<p> Tot i que el c\u00e0ncer de pulm\u00f3 \u00e9s un dels m\u00e9s estudiats a nivell gen\u00e8tic, encara falta molt cam\u00ed per poder identificar tots els gens que intervenen en l\u2019aparici\u00f3 i la progressi\u00f3 de la malaltia. <\/p>\n<p> La investigaci\u00f3 ha comptat amb la col\u00b7laboraci\u00f3 d\u2019investigadors del Centro Nacional de Investigaciones Oncol\u00f3gicas de Madrid (CNIO), del Hospital Virgen de la Arrixaca de M\u00farcia, del Hospital Universitario Madrid Sanchinarro i de l\u2019Institut Nacional de Bioinform\u00e0tica de Madrid. Ha comptat amb el finan\u00e7ament del Ministeri de Ci\u00e8ncia i Innovaci\u00f3 i de l\u2019Associaci\u00f3 Espanyola Contra el C\u00e0ncer. <\/p>\n<p> <strong>Refer\u00e8ncia de l\u2019article<\/strong> <strong><\/p>\n<p><\/strong> <strong>Rodriguez-Nieto S*<\/strong>, Ca\u00f1ada A, <strong>Pros E*<\/strong>, <strong>Pinto AI*<\/strong>, Torres-Lanzas J, Lopez-Rios F, Sanchez-Verde L, Pisano DG, <strong>Sanchez-Cespedes M<\/strong>. Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1\/SMARCA4 in lung primary tumors. Hum Mutat. 2010 Dec 7. [Epub ahead of print]. <\/p>\n<p> <strong>*Investigadors IDIBELL<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Una investigaci\u00f3 de l\u2019IDIBELL confirma que el gen supressor SMARCA4 est\u00e0 inactiu en tumors primaris de pulm\u00f3 Refer\u00e8ncia de l\u2019article  Rodriguez-Nieto S* Pros E* Pinto AI* Sanchez-Cespedes M *Investigadors IDIBELL<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 08:28:13","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9703"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9703"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9703\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}