L\u2019article, \u201cAntiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis\u201d, es va publicar el mes de mar\u00e7 de 2009 a la revista Cancer Cell, una de les m\u00e9s prestigioses en investigaci\u00f3 oncol\u00f2gica. Des de llavors ha rebut 226 cites; 46 durant els mesos de maig i juny de 2010, que \u00e9s el per\u00edode que ha avaluat Thomson Reuters per elaborar la seva classificaci\u00f3 de novembre i desembre. <\/p>\n
L\u2019article ha estat coordinat per Oriol Casanovas, investigador del grup d\u2019angiog\u00e8nesi tumoral de l\u2019IDIBELL i de l\u2019Institut Catal\u00e0 d\u2019Oncologia (ICO)<\/a>, i per Douglas Hanahan, investigador de la Universitat de California de San Francisco<\/a>. La primera signant de l\u2019estudi \u00e9s Marta P\u00e1ez-Ribes, investigadora predoctoral de l\u2019IDIBELL. El treball tamb\u00e9 ha comptat amb la participaci\u00f3 de l\u2019investigador de l\u2019IDIBELL i de la Universitat de Barcelona<\/a> Francesc Vi\u00f1als. <\/p>\n L\u2019estudi ofereix una explicaci\u00f3 a un fenomen que fa anys que desconcerta els especialistes en oncologia. Els tumors \u201cfabriquen\u201d vasos sanguinis que els supleixen aliment per poder cr\u00e9ixer i reproduir-se. Aquest fenomen rep el nom d\u2019angiog\u00e8nesi. Quan es va descobrir, de seguida es va veure una oportunitat per desenvolupar f\u00e0rmacs que bloquegessin la proliferaci\u00f3 de vasos sanguinis al voltant del tumor, els anomenats f\u00e0rmacs anti-angiog\u00e8nics. <\/p>\n En aquest treball, els investigadors han demostrat en experiments amb ratolins que amb aquestes ter\u00e0pies es produeix un descens inicial del nombre de c\u00e8l\u00b7lules tumorals, per\u00f2 un temps despr\u00e9s el c\u00e0ncer s\u2019escampa amb rapidesa a altres \u00f2rgans i teixits (met\u00e0stasi). En concret, les c\u00e8l\u00b7lules malignes que sobreviuen despr\u00e9s de bloquejar l\u2019angiog\u00e8nesi s\u00f3n capaces de tolerar la falta d\u2019oxigen. Aquestes c\u00e8l\u00b7lules hip\u00f2xiques activen mecanismes que les ajuden a disseminar-se a altres teixits a trav\u00e9s del torrent sanguini normal. A m\u00e9s, les c\u00e8l\u00b7lules hip\u00f2xiques s\u00f3n m\u00e9s resistents a la quimioter\u00e0pia i a la radioter\u00e0pia. Aix\u00f2 explica la poca resposta dels pacients a aquests tractaments despr\u00e9s de rebre f\u00e0rmacs antiangiog\u00e8nics. Aquest descobriment obre la porta a noves estrat\u00e8gies de tractament. <\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> <\/p>\n <\/strong> P\u00e0ez-Ribes M*<\/strong>, Allen E, Hudock J, Takeda T, Okuyama H, Vi\u00f1als F*<\/strong>, Inoue M, Bergers G, Hanahan D, Casanovas O<\/strong>*. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009 Mar 3;15(3):220-31. <\/p>\n *Investigadors IDIBELL<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia de l\u2019article P\u00e0ez-Ribes M* Vi\u00f1als F* Casanovas O *Investigadors IDIBELL<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9702","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-09-14 17:07:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9702"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9702"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9702\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9702"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}