{"id":9661,"date":"2011-04-19T00:00:00","date_gmt":"2011-04-18T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2011\/04\/19\/henning-walczak-tenim-tots-els-mecanismes-al-nostre-abast-per-coneixer-lenemic-i-combatrel\/"},"modified":"2020-05-13T19:50:46","modified_gmt":"2020-05-13T17:50:46","slug":"henning-walczak-tenim-tots-els-mecanismes-al-nostre-abast-per-coneixer-lenemic-i-combatrel","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2011\/04\/henning-walczak-tenim-tots-els-mecanismes-al-nostre-abast-per-coneixer-lenemic-i-combatrel\/","title":{"rendered":"Henning Walczak: \u201cTenim tots els mecanismes al nostre abast per con\u00e8ixer l\u2019enemic i combatre\u2019l\u201d"},"content":{"rendered":"<p>El grup de recerca de Walczak t\u00e9 com a objectiu entendre com el sistema immune ataca espec\u00edficament al c\u00e0ncer i descobrir els mecanismes utilitzats pels tumors per contrarestar aquests atacs. L\u2019investigador ha explicat la seva recerca en la via de senyalitzaci\u00f3 de TRAIL (lligand <em>inductor<\/em> d\u2019apoptosi relacionat amb el factor de necrosi tumoral, TNF) per descobrir noves dianes terap\u00e8utiques que es puguin combinar amb altres f\u00e0rmacs i provoquin la mort de les c\u00e8l\u00b7lules tumorals. De manera que, ha explicat Walczak, \u201cpodrem predir si les combinacions amb f\u00e0rmacs agonistes del receptor de TRAIL es poden aplicar amb \u00e8xit o no en un pacient amb un tumor particular\u201d. De fet actualment hi ha diversos agonistes de TRAIL-R en fase d\u2019assaig cl\u00ednic per\u00f2 Henning Walczak opina que \u201cla l\u00f2gica de la ind\u00fastria no est\u00e0 permetent, de moment, trobar les combinacions de f\u00e0rmacs adequades i que puguin ser efectives per a un tractament personalitzat del c\u00e0ncer\u201d. <\/p>\n<p> Walczak tamb\u00e9 ha explicat els resultats d\u2019un estudi del seu grup publicat a la revista Nature que descriu com una prote\u00efna anomenada Sharpin interfereix en la mort cel\u00b7lular indu\u00efda per TNF, i per tant prev\u00e9 la inflamaci\u00f3. Els resultats, diu l\u2019investigador, evidencien la rellev\u00e0ncia de la ubiquitinaci\u00f3 linear in vivo en la prevenci\u00f3 de la inflamaci\u00f3 i en la regulaci\u00f3 del senyal immune. Coses que poden ser claus en el tractament de malalties inflamat\u00f2ries i autoimmunes com l\u2019artritis reum\u00e0tica o la malaltia de Cr\u00f6hn entre d\u2019altres.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El grup de recerca de Walczak t\u00e9 com a objectiu entendre com el sistema immune ataca espec\u00edficament al c\u00e0ncer i descobrir els mecanismes utilitzats pels tumors per contrarestar aquests atacs. L\u2019investigador ha explicat la seva recerca en la via de senyalitzaci\u00f3 de TRAIL (lligand inductor d\u2019apoptosi relacionat amb el factor de necrosi tumoral, TNF) per [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-08 15:43:46","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9661"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9661"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9661\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}