{"id":9626,"date":"2011-08-09T00:00:00","date_gmt":"2011-08-08T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2011\/08\/09\/un-canvi-epigenetic-en-determinades-cel%c2%b7lules-t-reguladores-podria-ser-un-biomarcador-de-pronostic-en-trasplantament-renal\/"},"modified":"2020-05-13T19:50:33","modified_gmt":"2020-05-13T17:50:33","slug":"un-canvi-epigenetic-en-determinades-cel%c2%b7lules-t-reguladores-podria-ser-un-biomarcador-de-pronostic-en-trasplantament-renal","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2011\/08\/un-canvi-epigenetic-en-determinades-cel%c2%b7lules-t-reguladores-podria-ser-un-biomarcador-de-pronostic-en-trasplantament-renal\/","title":{"rendered":"Un canvi epigen\u00e8tic en determinades c\u00e8l\u00b7lules T reguladores podria ser un biomarcador de pron\u00f2stic en trasplantament renal"},"content":{"rendered":"<p><strong>Un estudi del grup de Nefrologia i Trasplantament Renal de l&#8217;IDIBELL demostra que els pacients sotmesos a transplantament renal que presenten c\u00e8l\u00b7lules T reguladores amb alta expressi\u00f3 del factor FOXp3 demetilat, tant en sang com directament en l\u2019\u00f2rgan trasplantat, tenen una millor evoluci\u00f3 funcional de l\u2019empelt.<\/strong><\/p>\n<p>Aix\u00f2 es deu a que aquests c\u00e8l\u00b7lules preserven la seva activitat supressora enfront la resposta al\u00b7log\u00e8nica efectora (de rebuig a un \u00f2rgan no reconegut). Els resultats de la investigaci\u00f3 s\u2019han publicat en l\u2019edici\u00f3 electr\u00f2nica de la revista <a href=\"http:\/\/www.amjtrans.com\/view\/0\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">American Journal of Transplantation<\/span><\/a>.<\/p>\n<p>La funci\u00f3 m\u00e9s coneguda dels limf\u00f2cits o c\u00e8l\u00b7lules T en el context de l\u2019al\u00b7loimmunitat \u00e9s la resposta efectora o inflamat\u00f2ria,<\/p>\n<p>que \u00e9s precisament la que provoca el rebuig en el trasplantament d\u2019\u00f2rgans. Per\u00f2 existeix un subtipus de c\u00e8l\u00b7lules T, les reguladores, que tenen com a funci\u00f3 justament la regulaci\u00f3 i modulaci\u00f3 d\u2019aquesta resposta immunol\u00f2gica efectora: s\u00f3n immunosupressores i per tant molt interessants en el camp dels trasplantaments.<\/p>\n<p>El fenotip m\u00e9s conegut d\u2019aquestes c\u00e8l\u00b7lules \u00e9s el que presenta el factor de transcripci\u00f3 FOXp3 per\u00f2 en humans, no sempre que les c\u00e8l\u00b7lules T presenten aquest factor tenen funci\u00f3 reguladora. Per aix\u00f2 els investigadors de l\u2019IDIBELL van decidir caracteritzar l\u2019epigen\u00e8tica d\u2019aquestes c\u00e8l\u00b7lules. \u00c9s a dir estudiar les modificacions qu\u00edmiques presents a l\u2019ADN del factor de transcripci\u00f3 FOXp3.<\/p>\n<p>L\u2019estudi s\u2019ha realitzat en dos grups de pacients de trasplantament renal: uns amb rebuig agut i uns altres amb rebuig subcl\u00ednic (el funcionament de l\u2019\u00f2rgan trasplantat \u00e9s bo per\u00f2 quan es fa una bi\u00f2psia es detecten alts nivells de c\u00e8l\u00b7lules T que suggereixen un rebuig).<\/p>\n<p>\u201cEn pacients amb rebuig agut, les c\u00e8l\u00b7lules T presentaven una modificaci\u00f3 epigen\u00e8tica (una metilaci\u00f3) en el factor FOXp3\u201d ha explicat l\u2019investigador de l\u2019IDIBELL i primer signant de l\u2019article Oriol Bestard, \u201cmentre que els pacients amb rebuig subcl\u00ednic i una bona funci\u00f3 renal no tenien aquest canvi en FOXp3, el factor preservava un estat demetilat\u201d.<\/p>\n<p>Aix\u00ed, aquest canvi epigen\u00e8tic en FOXp3 serveix com a biomarcador de pron\u00f2stic per un trasplantament de rony\u00f3. Si est\u00e0 demetilat sabem que s\u00f3n c\u00e8l\u00b7lules amb funci\u00f3 reguladora de la resposta immunol\u00f2gica que ens ajudaran a controlar el rebuig de l\u2019\u00f2rgan.<\/p>\n<p>L\u2019objectiu final de la recerca \u00e9s evitar que els pacients sotmesos a un transplantament renal hagin de sotmetre\u2019s tamb\u00e9 a un tractament immunosupressor amb els efectes adversos que aix\u00f2 suposa. \u201cA Europa\u201d ha explicat Bestard , \u201cs\u2019han iniciat estudis cl\u00ednics preliminars amb<\/p>\n<p>ter\u00e0pies cel\u00b7lulars per infondre c\u00e8l\u00b7lules T reguladores als pacients trasplantats, amb els resultats d\u2019aquests estudis la ter\u00e0pia seria m\u00e9s precisa perqu\u00e8 infondr\u00edem nom\u00e9s les c\u00e8l\u00b7lules T reguladores amb el factor FOXp3 demetilat, que s\u00f3n realment aquelles que tenen activitat immunoreguladora\u201d.<\/p>\n<p><strong>Refer\u00e8ncia de l&#8217;article<\/strong><\/p>\n<p>Bestard O.*, Cu\u00f1etti L.*, Cruzado J.M.*, Lucia M.*, Valdez R.*, Olek S., Melilli E.*, Torras J.*, Mast R., Gom\u00e0 M., Franquesa M.* and Griny\u00f3 J.M.*. Intragraft regulatory T cells in protocol biopsies retain Foxp3 Demethylation and are protective biomarkers for kidney graft outcome. American Journal of Transplantation. doi: 10.1111\/j.1600-6143.2011.03633.x.<\/p>\n<p>* Investigadors de l&#8217;IDIBELL<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors de l\u2019IDIBELL demostren que la metilaci\u00f3 del factor FOXp3 en c\u00e8l\u00b7lules T reguladores controla la seva funci\u00f3 immunosupressora Un estudi del grup de Nefrologia i Trasplantament Renal de l&#8217;IDIBELL  demostra que els pacients sotmesos a transplantament renal que presenten  c\u00e8l\u00b7lules T reguladores amb alta expressi\u00f3 del factor FOXp3 demetilat,  tant en sang com directament en l\u2019\u00f2rgan trasplantat, tenen una millor  evoluci\u00f3 funcional de l\u2019empelt. Refer\u00e8ncia de l&#8217;article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,339],"tags":[],"class_list":["post-9626","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar","category-nefrologia-i-transplantament-renal"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 06:12:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9626"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9626\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9626"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9626"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}