{"id":9621,"date":"2011-09-02T00:00:00","date_gmt":"2011-09-01T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2011\/09\/02\/investigadors-de-lidibell-descobreixen-per-que-les-cel%c2%b7lules-tumorals-canvien-daspecte\/"},"modified":"2020-05-13T19:50:30","modified_gmt":"2020-05-13T17:50:30","slug":"investigadors-de-lidibell-descobreixen-per-que-les-cel%c2%b7lules-tumorals-canvien-daspecte","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2011\/09\/investigadors-de-lidibell-descobreixen-per-que-les-cel%c2%b7lules-tumorals-canvien-daspecte\/","title":{"rendered":"Investigadors de l\u2019IDIBELL descobreixen per qu\u00e8 les c\u00e8l\u00b7lules tumorals canvien d\u2019aspecte"},"content":{"rendered":"<p><strong>Com les serps, les c\u00e8l\u00b7lules tumorals muden la pell. I \u00e9s que el c\u00e0ncer  no \u00e9s una malaltia est\u00e0tica sin\u00f3 que en el seu desenvolupament va  acumulant transformacions per evadir les defenses naturals del nostre  organisme i adaptar-se a les noves circumst\u00e0ncies de l&#8217;entorn.<\/strong> <\/p>\n<p> Fins ara es coneixia poca cosa dels mecanismes implicats en aquests processos de canvi d&#8217;un tumor. Existeix una via particularment intrigant en qu\u00e8 un tumor que inicialment presenta un estat s\u00f2lid, adherit a les c\u00e8l\u00b7lules properes (epitelial), es converteix en una massa m\u00e9s l\u00edquida, desenganxada dels teixits annexos i m\u00e9s flexible (mesenquimal). <\/p>\n<p> L&#8217;equip dirigit per Manel Esteller, director del Programa d&#8217;Epigen\u00e8tica i Biologia del C\u00e0ncer de l&#8217;Institut de Recerca Biom\u00e8dica de Bellvitge (IDIBELL), professor de Gen\u00e8tica de la Universitat de Barcelona i Investigador ICREA, ha identificat un mecanisme que explica aquest canvi. Els tumors que \u201cmuden la seva pell\u201d ho fan perqu\u00e8 s&#8217;apaguen uns interruptors moleculars anomenats microARNs que s\u00f3n els guardians responsables de mantenir l&#8217;aspecte epitelial de les c\u00e8l\u00b7lules. La troballa es publica aquesta setmana en la versi\u00f3 digital de la revista cient\u00edfica internacional Oncogene, del grup Nature. <\/p>\n<p> \u201cL&#8217;estudi consisteix en el descobriment que uns microARNs, del grup anomenat microARNs-200S, pateix una inactivaci\u00f3 qu\u00edmica per la qual deixen de expressar-se. En no estar presents aquests controladors de l&#8217;aspecte cel\u00b7lular, les c\u00e8l\u00b7lules tumorals canvien, s&#8217;estiren, deixen d&#8217;inhibir-se i el tumor progressa\u201d, explica el doctor Esteller, i afegeix que \u201cels resultats derivats de la investigaci\u00f3 demostren que aquest \u00e9s un proc\u00e9s molt din\u00e0mic.\u201d <\/p>\n<p> El canvi succeeix des de l\u2019aparici\u00f3 del tumor fins a l\u2019aparici\u00f3 de la met\u00e0stasi, per\u00f2 si canviem les circumst\u00e0ncies ambientals que influeixen en aquestes c\u00e8l\u00b7lules, el proc\u00e9s es reverteix. Segons explica el director del programa d\u2019epigen\u00e8tica de l\u2019IDIBELL, \u201cpodem pensar que un tumor \u00e9s com un petit planeta en evoluci\u00f3 darwiniana per\u00f2 de manera accelerada.\u201d <\/p>\n<p> L\u2019estudi s\u2019ha realitzat principalment en tumors de mama i c\u00f2lon. A m\u00e9s de servir per con\u00e8ixer millor la malaltia, els resultats s\u00f3n importants perqu\u00e8 permeten predir que \u00e9s possible intervenir externament en el proc\u00e9s. En aquest sentit, mitjan\u00e7ant tractaments farmacol\u00f2gics es podria revertir el proc\u00e9s i passar d\u2019una forma molt evolucionada del tumor a una m\u00e9s primitiva, cosa que aniria associada a una menor progressi\u00f3 de la malaltia. <\/p>\n<p> <strong>Refer\u00e8ncia de l\u2019article<\/strong> <strong><\/p>\n<p><\/strong> V Davalos*, C Moutinho*, A Villanueva*, R Boque*, P Silva, F Carneiro, and M Esteller*. Dynamic epigenetic regulation of the micro RNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. 2011 Aug 29. doi: 10.1038\/onc.2011.383. [Epub ahead of print] <\/p>\n<p> *Investigadors de l\u2019IDIBELL<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Si es canvien les condicions ambientals dels tumors, el proc\u00e9s es reverteix  L\u2019estudi ha estat liderat per l\u2019investigador Manel Esteller Com les serps, les c\u00e8l\u00b7lules tumorals muden la pell. I \u00e9s que el c\u00e0ncer  no \u00e9s una malaltia est\u00e0tica sin\u00f3 que en el seu desenvolupament va  acumulant transformacions per evadir les defenses naturals del nostre  organisme i adaptar-se a les noves circumst\u00e0ncies de l&#8217;entorn. Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9621","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-12-01 00:35:55","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9621"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9621\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}