Noves estrat\u00e8gies terap\u00e8utiques<\/strong> <\/p>\n En aquest sentit, en els \u00faltims anys ha crescut l\u2019inter\u00e8s per estudiar el metabolisme tumoral com a possible diana terap\u00e8utica. Diverses vies metab\u00f2liques presenten diferents funcions en c\u00e8l\u00b7lules tumorals i en c\u00e8l\u00b7lules sanes. En concret, la glic\u00f2lisi (oxidaci\u00f3 de la glucosa per obtenir energia) augmenta en algunes c\u00e8l\u00b7lules tumorals. Aix\u00f2 les fa particularment sensibles a inhibidors de la glic\u00f2lisi com la 2-deoxiglucosa. <\/p>\n
L\u2019estudi, coordinat per la cap del grup de Regulaci\u00f3 de la Mort Cel\u00b7lular, Cristina Mu\u00f1oz-Pinedo, i el cap de grup de Sarcomes, \u00d2scar Mart\u00ednez-Tirado demostra que \u201cin vitro\u201d aquesta mol\u00e8cula inhibeix el metabolisme de la glucosa que la c\u00e8l\u00b7lula tumoral necessita, provocant la seva mort. Segons la investigadora Cristina Mu\u00f1oz-Pinedo aquesta mol\u00e8cula \u201cfrena el creixement de les c\u00e8l\u00b7lules tumorals, els provoca la mort i un percentatge d\u2019elles pateix una diferenciaci\u00f3 terminal, i presenten l\u2019aspecte de c\u00e8l\u00b7lules musculars sanes.\u201d <\/p>\n
Aquesta mol\u00e8cula tamb\u00e9 \u00e9s molt semblant a la que es fa servir en les t\u00e8cniques d\u2019imatge PET que s\u2019utilitzen per diagnosticar tumors que tenen un elevat metabolisme de la glucosa. Aix\u00f2, i el fet que ja s\u2019estan realitzant assaigs cl\u00ednics amb altres tumors, demostren que, a dosis altes, aquesta mol\u00e8cula \u00e9s poc t\u00f2xica i seria relativament f\u00e0cil poder-la fer servir en tractaments de rabdomiosarcoma alveolar. <\/p>\n
Mu\u00f1oz-Pinedo ha afegit que \u201cel fet de con\u00e8ixer el mecanisme cel\u00b7lular que provoca la mort d\u2019aquests c\u00e8l\u00b7lules tumorals permetr\u00e0, en el futur, afinar m\u00e9s en els tractaments i fer-los m\u00e9s personalitzats\u201d. <\/p>\n
Refer\u00e8ncia de l\u2019article<\/strong> <\/p>\n<\/strong> Silvia Ram\u00edrez-Peinado, Ferm\u00edn Alc\u00e1zar-Limones, Laura Lagares-Tena, Nadia El Mjiyad, Alfredo Caro-Maldonado, Tirado OM and<\/p>\n
Cristina Mu\u00f1oz Pinedo. 2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma.<\/p>\n
Cancer Research doi:10.1158\/0008-5472.CAN-11-0759.<\/p>\n","protected":false},"excerpt":{"rendered":"
Una mol\u00e8cula semblant a la glucosa provoca in vitro la mort de les c\u00e8l\u00b7lules tumorals del rabdomiosarcoma alveolar Noves estrat\u00e8gies terap\u00e8utiques Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,333,398],"tags":[],"class_list":["post-9618","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar","category-metabolisme-i-mort-cellular","category-sarcoma"],"publishpress_future_action":{"enabled":false,"date":"2025-01-01 11:32:20","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9618"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9618\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9618"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}