{"id":9602,"date":"2011-10-28T00:00:00","date_gmt":"2011-10-27T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2011\/10\/28\/les-cel%c2%b7lules-tumorals-de-colon-que-fan-metastasi-al-fetge-es-tornen-mes-agressives-com-a-resposta-al-nou-microambient-hostil\/"},"modified":"2020-05-13T19:50:20","modified_gmt":"2020-05-13T17:50:20","slug":"les-cel%c2%b7lules-tumorals-de-colon-que-fan-metastasi-al-fetge-es-tornen-mes-agressives-com-a-resposta-al-nou-microambient-hostil","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2011\/10\/les-cel%c2%b7lules-tumorals-de-colon-que-fan-metastasi-al-fetge-es-tornen-mes-agressives-com-a-resposta-al-nou-microambient-hostil\/","title":{"rendered":"Les c\u00e8l\u00b7lules tumorals de c\u00f2lon que fan met\u00e0stasi al fetge es tornen m\u00e9s agressives com a resposta al nou microambient hostil"},"content":{"rendered":"<p><strong>Determinades   c\u00e8l\u00b7lules sanes del fetge promouen una resposta adaptativa en  c\u00e8l\u00b7lules  de c\u00e0ncer colorectal inhibint la seva proliferaci\u00f3 i  provocant la seva  mort. Les c\u00e8l\u00b7lules tumorals que s\u2019adapten canvien el  seu comportament i  la seva morfologia, afavorint-ne la migraci\u00f3.  Investigadors de  l\u2019IDIBELL i de l\u2019<a href=\"http:\/\/www.iconcologia.net\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Institut Catal\u00e0 dl\u2019Oncologia<\/span><\/a> (ICO), coordinats per David Garc\u00eda Mollev\u00ed, han publicat els resultats d\u2019aquest estudi a la revista <a href=\"http:\/\/www.neoplasia.com\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Neoplasia<\/span><\/a>.<\/strong> <\/p>\n<p> El   microambient cel\u00b7lular (anomenat estroma) t\u00e9 un paper dual en el   control del desenvolupament normal o maligne de les c\u00e8l\u00b7lules: per una   banda impedeix el creixement de proliferaci\u00f3 anormal (neopl\u00e0sia) en els   teixits normals mentre que per l\u2019altra pot potenciar el creixement i la   invasi\u00f3 tumoral en la progressi\u00f3 del c\u00e0ncer. <\/p>\n<p> El   c\u00e0ncer \u00e9s un teixit complex on actuen diferents tipus de c\u00e8l\u00b7lules (el   80% s\u00f3n d\u2019un tipus anomenat fibroblasts) que conviuen amb altres   c\u00e8l\u00b7lules creant un microambient particular. El balan\u00e7 entre aquestes   poblacions: l\u2019ambient, pot determinar el dest\u00ed del tumor. <\/p>\n<p> <strong>Un microambient hostil<\/strong> <\/p>\n<p> L\u2019objectiu   de l\u2019estudi \u00e9s comparar la influ\u00e8ncia del microambient<\/p>\n<p> en tres   situacions diverses: en un teixit colorectal sa, en un tumor colorectal   primari i en un tumor colorectal que ha fet met\u00e0stasi al fetge. <\/p>\n<p> En   el tumor primari, els fibroblasts del c\u00f2lon augmenten la proliferaci\u00f3   de les c\u00e8l\u00b7lules malignes i les protegeixen de la mort cel\u00b7lular   programada (apoptosi). En canvi, en la situaci\u00f3 de met\u00e0stasi al fetge,   les c\u00e8l\u00b7lules tumorals es troben en un ambient hostil de fibroblasts   hep\u00e0tics, no nom\u00e9s disminueix la seva proliferaci\u00f3, sin\u00f3 que moltes   moren. Les c\u00e8l\u00b7lules que aconsegueixen adaptar-se a aquest ambient   canvien el seu comportament i la seva morfologia per afavorir la seva   migraci\u00f3. Aquestes c\u00e8l\u00b7lules tumorals adaptades s\u00f3n m\u00e9s agressives. <\/p>\n<p> Segons   David Garcia Mollev\u00ed, coordinador de l\u2019estudi, aquest descobriment pot   ser \u00fatil a la pr\u00e0ctica cl\u00ednica ja qu\u00e8 \u201cobre les obres a estudiar el   mecanisme o els factors dels fibroblasts hep\u00e0tics que produeixen la mort   de les c\u00e8l\u00b7lules tumorals colorectals per utilitzar-los en el futur  com  a eines terap\u00e8utiques contra el tumor de c\u00f2lon metast\u00e0tic\u201d. <\/p>\n<p> <strong>Refer\u00e8ncia de l\u2019article<\/strong> <strong><br \/><\/strong> Mireia   Berdiel-Acer, Monika Bohem, Adriana L\u00f3pez-Doriga, August Vidal, Ramon   Salazar, Maria Mart\u00ednez-Iniesta, Cristina Santos, Xavier Sanjuan,   Alberto Villanueva and David G. Mollev\u00ed. <em>Hepatic Carcinoma-associated   fibroblasts promote an adaptative response in colorectal cancer cells   that inhibit proliferation and apoptosis<\/em>.<strong> <\/strong>Neoplasia. Volume 13 Number 10 October 2011 pp. 931<em>\u2013<\/em>946<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La majoria de les c\u00e8l\u00b7lules malignes moren, nom\u00e9s sobreviuen les que aconsegueixen adaptar-se Determinades   c\u00e8l\u00b7lules sanes del fetge promouen una resposta adaptativa en  c\u00e8l\u00b7lules  de c\u00e0ncer colorectal inhibint la seva proliferaci\u00f3 i  provocant la seva  mort. Les c\u00e8l\u00b7lules tumorals que s\u2019adapten canvien el  seu comportament i  la seva morfologia, afavorint-ne la migraci\u00f3.  Investigadors de  l\u2019IDIBELL i de l\u2019Institut Catal\u00e0 dl\u2019Oncologia (ICO), coordinats per David Garc\u00eda Mollev\u00ed, han publicat els resultats d\u2019aquest estudi a la revista Neoplasia. Un microambient hostil Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-23 20:55:12","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9602"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9602"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9602\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9602"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9602"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}