{"id":9601,"date":"2011-10-28T00:00:00","date_gmt":"2011-10-27T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2011\/10\/28\/marcus-buschbeck-encara-no-entenem-com-sordena-la-biblioteca-on-semmagatzema-ladn\/"},"modified":"2020-05-13T19:50:18","modified_gmt":"2020-05-13T17:50:18","slug":"marcus-buschbeck-encara-no-entenem-com-sordena-la-biblioteca-on-semmagatzema-ladn","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2011\/10\/marcus-buschbeck-encara-no-entenem-com-sordena-la-biblioteca-on-semmagatzema-ladn\/","title":{"rendered":"Marcus Buschbeck: \u201cEncara no entenem com s\u2019ordena la biblioteca on s\u2019emmagatzema l\u2019ADN\u201d"},"content":{"rendered":"<p>L\u2019investigador Marcus Buschbeck de l\u2019<a href=\"http:\/\/www.imppc.org\/ca\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Institut de Medicina Predictiva i Personalitzada del C\u00e0ncer<\/span><\/a> (IMPPC) de Badalona ha explicat els seus darrers aven\u00e7os en la recerca d\u2019una prote\u00efna relacionada amb l\u2019empaquetament de l\u2019ADN i la seva implicaci\u00f3 en la diferenciaci\u00f3 cel\u00b7lular el 21 d\u2019octubre dins el cicle de seminaris IDIBELL. <\/p>\n<p> L\u2019objectiu del grup de Buschbeck \u00e9s entendre com una c\u00e8l\u00b7lula canvia el seu fenotip i com es regula el seu nivell de cromatina. \u00c9s a dir com s\u2019empaqueta la informaci\u00f3 de l\u2019ADN. Segons l\u2019investigador , si imaginem una biblioteca, \u201cels llibres serien l\u2019ADN i la forma en que es reparteixen per les seccions, les taules o els magatzems seria l\u2019epigen\u00e8tica que fa que alguna informaci\u00f3 tingui m\u00e9s import\u00e0ncia que altra. Encara no entenem l\u2019estructura de la biblioteca\u201d. <\/p>\n<p> Per entendre-la millor estudien la variant d\u2019histona MacroH2A i han vist que est\u00e0 implicada en la diferenciaci\u00f3 cel\u00b7lular \u201cno nom\u00e9s en el desenvolupament embrionari sin\u00f3 tamb\u00e9 en teixits ja existents, de manera que podria tenir una paper en el desenvolupament de c\u00e0ncer\u201d. <\/p>\n<p> \u201cEl repte \u00e9s entendre els canvis epigen\u00e8tics implicats en el c\u00e0ncer i utilitzar aquesta informaci\u00f3 ja sigui per la recerca de nous tractaments, o m\u00e9s important encara, per fer un diagn\u00f2stic preco\u00e7 del c\u00e0ncer. En un futur hem de ser capa\u00e7os de detectar l\u2019alteraci\u00f3 epigen\u00e8tica abans que es desenvolupi el c\u00e0ncer\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019investigador Marcus Buschbeck de l\u2019Institut de Medicina Predictiva i Personalitzada del C\u00e0ncer (IMPPC) de Badalona ha explicat els seus darrers aven\u00e7os en la recerca d\u2019una prote\u00efna relacionada amb l\u2019empaquetament de l\u2019ADN i la seva implicaci\u00f3 en la diferenciaci\u00f3 cel\u00b7lular el 21 d\u2019octubre dins el cicle de seminaris IDIBELL. L\u2019objectiu del grup de Buschbeck \u00e9s entendre [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9601","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 06:27:01","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9601"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9601\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}