Aquesta \u00e9s la gran pregunta que mou tota la recerca al laboratori de Sistemes Gen\u00e8tics que dirigeix l\u2019investigador ICREA Ben Lehner al Centre de Regulaci\u00f3 Gen\u00f2mica de Barcelona. Lehner ha explicat els seus darrers aven\u00e7os dins el cicle de seminaris de l\u2019IDIBELL el passat 4 de novembre. <\/p>\n
El grup de Lehner pret\u00e9n entendre per qu\u00e8 dos individus id\u00e8ntics gen\u00e8ticament, que presenten una mateixa mutaci\u00f3, no sempre presenten el mateix fenotip. \u201cEn humans, aix\u00f2 s\u2019acostuma a explicar per l\u2019ambient. \u00c9s per aix\u00f2 que estudiem organismes m\u00e9s simples al laboratori on es poden controlar els factors ambientals i amb els quals es poden repetir els experiments moltes vegades. I hem vist que ha d\u2019existir algun altre mecanisme que expliqui per qu\u00e8 individus iguals en condicions ambientals controlades no presenten el mateix fenotip\u201d. <\/p>\n
Lehner treballa amb llevats i amb C.elegans i el que ha vist \u00e9s que \u201cl\u2019expressi\u00f3 gen\u00e8tica dep\u00e8n dels gens i l\u2019ambient per\u00f2 tamb\u00e9 interv\u00e9 una variaci\u00f3 que es deu a l\u2019atzar. No es tracta d\u2019un interruptor amb les dues posicions on\/off i ja est\u00e0. Hi ha alguna cosa m\u00e9s\u201d. <\/p>\n
Ben Lehner utilitza an\u00e0lisis experimentals i computacionals per entendre els principis i l\u2019evoluci\u00f3 dels sistemes gen\u00e8tics. La seva recerca se centra en entendre i poder predir com les mutacions donen com a resultat canvis fenot\u00edpics, i com aquestes mutacions es combinen per causar malalties, l\u2019evoluci\u00f3 i la import\u00e0ncia de la redund\u00e0ncia gen\u00e8tica, l\u2019evoluci\u00f3 de les xarxes de regulaci\u00f3 i la interacci\u00f3 entre el soroll, la plasticitat i el potencial evolutiu.<\/p>\n","protected":false},"excerpt":{"rendered":"
Aquesta \u00e9s la gran pregunta que mou tota la recerca al laboratori de Sistemes Gen\u00e8tics que dirigeix l\u2019investigador ICREA Ben Lehner al Centre de Regulaci\u00f3 Gen\u00f2mica de Barcelona. Lehner ha explicat els seus darrers aven\u00e7os dins el cicle de seminaris de l\u2019IDIBELL el passat 4 de novembre. El grup de Lehner pret\u00e9n entendre per qu\u00e8 […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 07:07:17","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9597"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9597"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9597\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}