{"id":9591,"date":"2011-11-23T00:00:00","date_gmt":"2011-11-22T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2011\/11\/23\/jean-ehrland-ricci-investiguem-com-la-inhibicio-de-la-glucolisi-pot-influir-en-una-resposta-immune-anti-cancer\/"},"modified":"2023-03-03T16:08:03","modified_gmt":"2023-03-03T15:08:03","slug":"jean-ehrland-ricci-investiguem-com-la-inhibicio-de-la-glucolisi-pot-influir-en-una-resposta-immune-anti-cancer","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2011\/11\/jean-ehrland-ricci-investiguem-com-la-inhibicio-de-la-glucolisi-pot-influir-en-una-resposta-immune-anti-cancer\/","title":{"rendered":"Jean-Ehrland Ricci: \u201cInvestiguem com la inhibici\u00f3 de la gluc\u00f2lisi pot influir en una resposta immune anti-c\u00e0ncer\u201d"},"content":{"rendered":"<p>L\u2019investigador de l\u2019<a href=\"http:\/\/www.inserm.fr\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">INSERM<\/span><\/a> (Institut Nacional Franc\u00e8s de la Salut i la Recerca M\u00e8dica) Jean-Ehrland Ricci estudia les relacions entre la gluc\u00f2lisi, la mort cel\u00b7lular i la resposta immune en c\u00e8l\u00b7lules tumorals. Ha explicat els darrers aven\u00e7os de la seva investigaci\u00f3 al cicle de seminaris IDIBELL el 18 de novembre.<\/p>\n<p>La majoria de les c\u00e8l\u00b7lules canceroses presenten un augment de la glic\u00f2lisis per a la generaci\u00f3 del seu subministrament d&#8217;energia (anomenat efecte Warburg). Aquesta especificitat est\u00e0 sent explorada per nombrosos laboratoris i companyies farmac\u00e8utiques per tractar de matar preferentment a aquestes c\u00e8l\u00b7lules.<\/p>\n<p>\u201cS\u2019ha demostrat que la inhibici\u00f3 del metabolisme de la glucosa fa que les c\u00e8l\u00b7lules siguin m\u00e9s sensibles a l\u2019apoptosi (mort cel\u00b7lular)\u201d ha explicat Ricci \u201cde manera que en un context de quimioresist\u00e8ncia o quan es fa necessari reduir el tractament de quimioter\u00e0pia per la seva alta toxicitat, combinar-hi la inhibici\u00f3 de la gluc\u00f2lisi podria millorar el tractament. De fet, en models animals, \u00e9s aix\u00ed\u201d.<\/p>\n<p>Pel que fa la relaci\u00f3 entre la gluc\u00f2lisi i una resposta immune anti-c\u00e0ncer \u201ccal tenir en compte que la inhibici\u00f3 del metabolisme de la glucosa fa que morin m\u00e9s c\u00e8l\u00b7lules per\u00f2 ho fa a trav\u00e9s de vies diferents. En aquest sentit, des del nostre laboratori estem estudiant com utilitzar la gluc\u00f2lisi com a diana, en combinaci\u00f3 amb quimoter\u00e0pia, pot influir en la inducci\u00f3 d\u2019una resposta del sistema immune que serveixi per controlar els tumors i les possibles recaigudes\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019investigador de l\u2019INSERM (Institut Nacional Franc\u00e8s de la Salut i la Recerca M\u00e8dica) Jean-Ehrland Ricci estudia les relacions entre la gluc\u00f2lisi, la mort cel\u00b7lular i la resposta immune en c\u00e8l\u00b7lules tumorals. Ha explicat els darrers aven\u00e7os de la seva investigaci\u00f3 al cicle de seminaris IDIBELL el 18 de novembre. La majoria de les c\u00e8l\u00b7lules canceroses [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":23137,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9591","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 06:01:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9591"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9591\/revisions"}],"predecessor-version":[{"id":23138,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9591\/revisions\/23138"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23137"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}