{"id":9555,"date":"2012-02-09T00:00:00","date_gmt":"2012-02-08T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2012\/02\/09\/jesus-garcia-foncillas-nomes-un-de-cada-deu-assaigs-first-in-human-funciona-pero-hem-de-continuar-provant\/"},"modified":"2023-03-02T16:12:45","modified_gmt":"2023-03-02T15:12:45","slug":"jesus-garcia-foncillas-nomes-un-de-cada-deu-assaigs-first-in-human-funciona-pero-hem-de-continuar-provant","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2012\/02\/jesus-garcia-foncillas-nomes-un-de-cada-deu-assaigs-first-in-human-funciona-pero-hem-de-continuar-provant\/","title":{"rendered":"Jes\u00fas Garc\u00eda-Foncillas: \u201cNom\u00e9s un de cada deu assaigs \u2018first in human\u2019 funciona, per\u00f2 hem de continuar provant\u201d"},"content":{"rendered":"

L\u2019investigador Jes\u00fas Garc\u00eda-Foncillas s\u2019ha incorporat recentment a l\u2019Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria \u2018Fundaci\u00f3n Jim\u00e9nez D\u00edaz\u2019<\/a> com a director de la Unitat de Recerca en C\u00e0ncer. All\u00e0 continua amb la recerca en el camp dels microRNA, com controlen la expressi\u00f3 de gens i com poden ser \u00fatils en la cl\u00ednica. Ha explicat els seus aven\u00e7os al seminari IDIBELL del 3 de febrer.<\/p>\n

Els microRNA s\u00f3n seq\u00fc\u00e8ncies curtes capaces de bloquejar o degradar seq\u00fc\u00e8ncies de RNA missatgers, encarregats de produir prote\u00efnes. Depenent de quin RNA missatger bloquegin tenen un paper o un altre. \u201cSi s\u2019uneixen a un RNA missatger que codifica un gen supressor, el microRNA tindr\u00e0 un efecte oncog\u00e8nic; si actua sobre el RNA missatger d\u2019un oncogen, ser\u00e0 antioncog\u00e8nic\u201d ha explicat Garc\u00eda-Foncillas.<\/p>\n

El seu equip investiga els m\u00faltiples mecanismes alternatius dels microRNA per regular l\u2019expressi\u00f3 dels gens \u201ccal tenir en compte que un \u00fanic microRNA es pot unir a entre 20 i 40 RNA missatgers diferents amb efectes diversos, tamb\u00e9 cal tenir en compte els canvis epigen\u00e8tics i els petits canvis en la seq\u00fc\u00e8ncia de nucle\u00f2tids del microRNA que transcendiran a aquests 20 o 40 gens…\u201d. \u201cEl m\u00e9s important\u201d explica Garc\u00eda-Foncillas \u201c\u00e9s com podem aplicar el coneixement d\u2019aquests mecanismes a la pr\u00e0ctica cl\u00ednica\u201d.<\/p>\n

\u201cHem vist que alguns microRNA tenen factor pron\u00f2stic en c\u00e0ncer g\u00e0stric i en c\u00e0ncer de c\u00f2lon\u201d. \u00c9s a dir que pacients que presenten determinats microRNA que regulen l\u2019expressi\u00f3 de gens diana dels f\u00e0rmacs respondran d\u2019una manera determinada a aquest f\u00e0rmac. \u201cEl que pretenem \u00e9s crear vectors capa\u00e7os de portar la seq\u00fc\u00e8ncia de microRNA que fa a un pacient sensible al f\u00e0rmac fins a les c\u00e8l\u00b7lules diana\u201d.<\/p>\n

Actualment, l\u2019equip de Garc\u00eda-Foncillas est\u00e0 pendent de l\u2019aprovaci\u00f3 de dos assaigs cl\u00ednics \u2018first in human\u2019 (de primera administraci\u00f3 en humans). \u201cEn recerca per aconseguir un petit \u00e8xit has de passar per diversos fracassos. Per la meva experi\u00e8ncia, nom\u00e9s un de cada deu d\u2019aquests assaigs \u2018first in human\u2019 funcionen, per\u00f2 hem de continuar provant\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"

L\u2019investigador Jes\u00fas Garc\u00eda-Foncillas s\u2019ha incorporat recentment a l\u2019Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria \u2018Fundaci\u00f3n Jim\u00e9nez D\u00edaz\u2019 com a director de la Unitat de Recerca en C\u00e0ncer. All\u00e0 continua amb la recerca en el camp dels microRNA, com controlen la expressi\u00f3 de gens i com poden ser \u00fatils en la cl\u00ednica. Ha explicat els seus aven\u00e7os al seminari IDIBELL […]<\/p>\n","protected":false},"author":6,"featured_media":23082,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 11:50:51","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9555"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9555"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9555\/revisions"}],"predecessor-version":[{"id":23083,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9555\/revisions\/23083"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23082"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}