{"id":9545,"date":"2012-02-29T00:00:00","date_gmt":"2012-02-28T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2012\/02\/29\/luis-serrano-modificar-la-concentracio-duna-proteina-un-canvi-epigenetic-pot-donar-com-a-resultat-una-malaltia\/"},"modified":"2023-03-02T14:47:07","modified_gmt":"2023-03-02T13:47:07","slug":"luis-serrano-modificar-la-concentracio-duna-proteina-un-canvi-epigenetic-pot-donar-com-a-resultat-una-malaltia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2012\/02\/luis-serrano-modificar-la-concentracio-duna-proteina-un-canvi-epigenetic-pot-donar-com-a-resultat-una-malaltia\/","title":{"rendered":"Luis Serrano: \u201cModificar la concentraci\u00f3 d\u2019una prote\u00efna, un canvi epigen\u00e8tic, pot donar com a resultat una malaltia\u201d"},"content":{"rendered":"<p>El director del <a href=\"http:\/\/pasteur.crg.es\/portal\/page\/portal\/Internet\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Centre de Regulaci\u00f3 Gen\u00f2mica<\/span><\/a> (CRG) de Barcelona, Luis Serrano, va explicar els \u00faltims aven\u00e7os del seu grup de recerca en Biologia de Sistemes en una conferencia del cicle de seminaris IDIBELL el 24 de febrer.<\/p>\n<p>Un dels punts d\u2019inter\u00e8s de l\u2019equip de Serrano \u00e9s estudiar les prote\u00efnes, no com a mol\u00e8cules a\u00efllades, sin\u00f3 com a parts d\u2019un sistema que \u00e9s m\u00e9s que la suma dels seus components biol\u00f2gics. \u201cles prote\u00efnes no estan soles a la c\u00e8l\u00b7lula, sempre estan lligades a altres prote\u00efnes, formant diversos complexes&#8230; i la compet\u00e8ncia entre aquestes prote\u00efnes per unir-se a altres afecta a les vies de senyalitzaci\u00f3 i pot derivar en alteracions de l\u2019expressi\u00f3 g\u00e8nica\u201d.<\/p>\n<p>\u00c9s per aix\u00f2 que una de les l\u00ednees de recerca de Serrano \u00e9s estudiar com la concentraci\u00f3 de prote\u00efnes a la c\u00e8l\u00b7lula pot provocar malalties: \u201cFins fa uns anys es pensava que les malalties eren resultat d\u2019una mutaci\u00f3 gen\u00e8tica, ara estem demostrant que nom\u00e9s variar la concentraci\u00f3 d\u2019una prote\u00efna, i aix\u00f2 \u00e9s un canvi epigen\u00e8tic, pot tenir com a resultat una malaltia sense necessita de cap mutaci\u00f3 inicial\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El director del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG) de Barcelona, Luis Serrano, va explicar els \u00faltims aven\u00e7os del seu grup de recerca en Biologia de Sistemes en una conferencia del cicle de seminaris IDIBELL el 24 de febrer. Un dels punts d\u2019inter\u00e8s de l\u2019equip de Serrano \u00e9s estudiar les prote\u00efnes, no com a mol\u00e8cules a\u00efllades, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":23053,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 11:30:20","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9545"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9545\/revisions"}],"predecessor-version":[{"id":23054,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9545\/revisions\/23054"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23053"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}