{"id":9544,"date":"2012-03-02T00:00:00","date_gmt":"2012-03-01T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2012\/03\/02\/lidibell-posa-en-marxa-una-plataforma-de-caenorhabditis-elegans\/"},"modified":"2023-03-02T14:42:50","modified_gmt":"2023-03-02T13:42:50","slug":"lidibell-posa-en-marxa-una-plataforma-de-caenorhabditis-elegans","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2012\/03\/lidibell-posa-en-marxa-una-plataforma-de-caenorhabditis-elegans\/","title":{"rendered":"L\u2019IDIBELL posa en marxa una plataforma de \u2018Caenorhabditis elegans\u2019"},"content":{"rendered":"<p><em>C. elegans<\/em> \u00e9s un nematode que fa un mil\u00b7l\u00edmetre de longitud, aproximadament. S\u2019ha utilitzat per estudiar la gen\u00e8tica del desenvolupament i el sistema nervi\u00f3s, i en els darrers anys est\u00e0 fent aportacions en l\u2019estudi de l\u2019envelliment, la mort cel\u00b7lular i l\u2019estructura del genoma. L\u2019any 1998 es va publicar la seq\u00fc\u00e8ncia completa del seu genoma, format per uns vint mil gens, un nombre similar al dels humans.<\/p>\n<p>La Plataforma de <em>C. elegans<\/em> de l\u2019IDIBELL neix amb la finalitat de facilitar l\u2019experimentaci\u00f3 en aquest nematode tant a investigadors no especialistes en el model, com a aquells que ja el coneixen per\u00f2 no disposen de la infraestructura o dels coneixements necessaris per dur a terme algunes t\u00e8cniques com per exemple la generaci\u00f3 de transg\u00e8nics. El servei est\u00e0 situat a la tercera planta de l\u2019Hospital Duran i Reynals, i est\u00e0 dirigit per Juli\u00e1n Cer\u00f3n i Alberto Villanueva. La coordinadora de la plataforma \u00e9s Montserrat Porta.<\/p>\n<p>Actualment, l\u2019organisme t\u00e9 un gran impacte en la recerca biom\u00e8dica. De fet, en els darrers anys dos premis Nobel de Medicina i Fisiologia han estat atorgats a investigadors que han realitzat la seva recerca amb aquest nematode. El curt cicle de vida aix\u00ed com la conservaci\u00f3 de gens i vies de senyalitzaci\u00f3 implicades en malalties humanes fan d\u2019aquest cuc un model molt atractiu per a validacions <em>in vivo<\/em>.<\/p>\n<p><em>C. elegans<\/em> presenta diverses caracter\u00edstiques que el fan especialment adient per a la recerca: \u00e9s transparent, cosa que facilita la seva observaci\u00f3 al microscopi; \u00e9s hermafrodita, cosa que afavoreix estudis gen\u00e8tics; \u00e9s un organisme simple amb un sistema nervi\u00f3s i digestiu ben definit i un nombre redu\u00eft de c\u00e8l\u00b7lules; \u00e9s f\u00e0cil de mantenir al laboratori; t\u00e9 una vida curta, de dues a tres setmanes, cosa que permet obtenir resultats en poc temps, i \u00e9s relativament senzill interrompre la funci\u00f3 dels seus gens mitjan\u00e7ant interfer\u00e8ncia per ARN (RNAi)<\/p>\n<p>&nbsp;<\/p>\n<p><strong><a class=\"enllac\" href=\"http:\/\/www.idibell.cat\/modul\/plataforma-c-elegans\/ca\">M\u00e9s informaci\u00f3<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>C. elegans \u00e9s un nematode que fa un mil\u00b7l\u00edmetre de longitud, aproximadament. S\u2019ha utilitzat per estudiar la gen\u00e8tica del desenvolupament i el sistema nervi\u00f3s, i en els darrers anys est\u00e0 fent aportacions en l\u2019estudi de l\u2019envelliment, la mort cel\u00b7lular i l\u2019estructura del genoma. L\u2019any 1998 es va publicar la seq\u00fc\u00e8ncia completa del seu genoma, format [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":23050,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,334,355,464],"tags":[],"class_list":["post-9544","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-medicina-translacional","category-models-de-malaltia-en-c-elegans","category-p-de-gens-malaltia-i-terapia"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 18:16:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9544"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9544\/revisions"}],"predecessor-version":[{"id":23051,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9544\/revisions\/23051"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23050"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}