L’aparici\u00f3 de met\u00e0stasi \u00e9s la responsable del 90% de morts en pacients amb c\u00e0ncer, de manera que entendre els mecanismes responsables d’aquest proc\u00e9s \u00e9s un dels objectius m\u00e0xims de la investigaci\u00f3 del c\u00e0ncer. El proc\u00e9s de met\u00e0stasi consisteix en una s\u00e8rie de passos encadenats en qu\u00e8 el tumor primari envaeix teixits ve\u00efns i acaba disseminant-se per tot l’organisme. Uns dels primers teixits que pateixen la met\u00e0stasi s\u00f3n els ganglis limf\u00e0tics que envolten el tumor.<\/p>\n
Un estudi liderat per l’investigador de l’IDIBELL, Manel Esteller, publicat en la prestigiosa revista The Journal of Pathology<\/em><\/a> identifica un mecanisme que explica com les c\u00e8l\u00b7lules tumorals s’escapen des del seu lloc original als ganglis limf\u00e0tics.Les investigacions desenvolupades han perm\u00e8s descobrir que les c\u00e8l\u00b7lules tumorals metast\u00e0tiques que creixen en els ganglis limf\u00e0tics dels pacients amb melanoma i tumors de cap i coll perden l’activitat d’una prote\u00efna denominada cadherina-11.<\/p>\n La funci\u00f3 normal d’aquesta prote\u00efna \u00e9s actuar com l’ancora d’un vaixell per fixar les c\u00e8l\u00b7lules en una posici\u00f3 concreta i evitar que es moguin. La inactivaci\u00f3 del gen de la cadherina-11 provoca que es perdi aquesta fixaci\u00f3 i fa que les c\u00e8l\u00b7lules tumorals \u201csaltin\u201d a \u00f2rgans i estructures ve\u00efnes, com s\u00f3n els ganglis limf\u00e0tics.<\/p>\n El treball de The Journal of Pathology<\/em> \u00e9s un exemple d’investigaci\u00f3 translacional i multidisciplin\u00e0ria, que ha implicat els laboratoris d’investigaci\u00f3 b\u00e0sica, el servei d’oncologia m\u00e8dica de l’Institut Catal\u00e0 de Oncologia<\/span><\/a> (ICO) i el servei d’Anatomia Patol\u00f2gica de l‘Hospital Universitari de Bellvitge<\/span><\/a>.<\/p>\n L’estudi coordinat pel director del Programa de Epigen\u00e8tica i Biologia del C\u00e0ncer de l’IDIBELL, investigador ICREA<\/span><\/a> i professor de la Universitat de Barcelona<\/span>,<\/a> Manel Esteller, tamb\u00e9 proposa que el proc\u00e9s pot ser reversible ja que, en models in vitro<\/em> i in vivo<\/em>, la recuperaci\u00f3 de l’activitat de la prote\u00efna cadherina-11 va causar un alentiment del creixement tumoral i una disminuci\u00f3 de la capacitat de generar met\u00e0stasi.<\/p>\n Aquesta possibilitat necessita ser estudiada en assaigs cl\u00ednics internacionals, per\u00f2 \u00e9s un punt de partida prometedor en l’estudi de l la biologia de la met\u00e0stasi i de com actuar terap\u00e8uticament en aquesta \u00e0rea.<\/p>\n <\/p>\n <\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> L’aparici\u00f3 de met\u00e0stasi \u00e9s la responsable del 90% de morts en pacients amb c\u00e0ncer, de manera que entendre els mecanismes responsables d’aquest proc\u00e9s \u00e9s un dels objectius m\u00e0xims de la investigaci\u00f3 del c\u00e0ncer. El proc\u00e9s de met\u00e0stasi consisteix en una s\u00e8rie de passos encadenats en qu\u00e8 el tumor primari envaeix teixits ve\u00efns i acaba disseminant-se […]<\/p>\n","protected":false},"author":6,"featured_media":23043,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,376,450,447,452,346],"tags":[],"class_list":["post-9543","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-epigenetica-del-cancer","category-malalties-de-cap-i-coll","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-procure","category-quimioresistencia-tumoral-i-estromal"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 13:09:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9543","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9543"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9543\/revisions"}],"predecessor-version":[{"id":23044,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9543\/revisions\/23044"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23043"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nCarmona FJ, Villanueva A, Vidal A, Mu\u00f1oz C, Puertas S, Penin RM, Gom\u00e0 M, Lujambio A, Piulats JM, Mes\u00eda R, S\u00e1nchez-C\u00e9spedes M, Man\u00f3s M, Condom E, Eccles SA, Esteller M. Epigenetic Disruption of Cadherin-11 in Human Cancer Metastasis. The Journal of Pathology<\/em>. 2012 Feb 28. doi: 10.1002\/path.4011
\n<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"