L\u2019estudi dels mecanismes moleculars que regulen<\/p>\n
les vies de senyalitzaci\u00f3 del Factor de Creixement Transformant (TGF-beta) \u00e9s el camp d\u2019actuaci\u00f3 de Peter Ten Djike i el grup de recerca que dirigeix a la Universitat de Leiden, a Holanda. Ten Djike ha explicat els seus \u00faltims aven\u00e7os en una confer\u00e8ncia dins el cicle de seminaris IDIBELL el 2 de mar\u00e7.<\/p>\n
El TGF-beta est\u00e0 implicat en la regulaci\u00f3 de diversos processos cel\u00b7lulars. Pel que fa els tumors, s\u2019ha demostrat que t\u00e9 una funci\u00f3 dual contradict\u00f2ria. D\u2019una banda, en estats inicials indueix la mort cel\u00b7lular programada, de manera que t\u00e9 una funci\u00f3 supressora del creixement del tumor, per\u00f2 en estats m\u00e9s avan\u00e7ats afavoreix la migraci\u00f3 i la invasi\u00f3 cel\u00b7lular i, per tant, la met\u00e0stasi.<\/p>\n
\u201cEstem interessats en aquest segon rol de TGF-beta\u201d ha explicat Ten Djike \u201cja qu\u00e8 la majoria de pacients no moren com a conseq\u00fc\u00e8ncia d\u2019un tumor primari sin\u00f3 de la seva expansi\u00f3 i met\u00e0stasi a altres parts del cos\u201d. El seu grup estudia en particular els receptors que participen en la via de senyalitzaci\u00f3 de TGF-beta que indueix la proliferaci\u00f3 \u201cs\u00f3n enzims i mol\u00e8cules que poden ser dianes terap\u00e8utiques en tractaments que inhibeixen l\u2019acci\u00f3 final del TGF-beta de promoure la met\u00e0stasi\u201d.<\/p>\n
Ten Dijke treballa amb diferents mol\u00e8cules que poden arribar a ser dianes potencials. Ha parlat del TRAF4 en c\u00e0ncer de pit \u201ces tracta d\u2019un regulador negatiu de la via de senyalitzaci\u00f3 del TGF-beta. Si inhibim aquest enzim, estem inhibint la migraci\u00f3, la invasi\u00f3 i per tant la met\u00e0stasi indu\u00efdes per TGF-beta en c\u00e8l\u00b7lules tumorals de c\u00e0ncer de pit\u201d.<\/p>\n
Una altra aproximaci\u00f3 que ja est\u00e0 en fase d\u2019assaig cl\u00ednic amb la participaci\u00f3 d\u2019una companyia farmac\u00e8utica \u00e9s la inhibici\u00f3 de l\u2019angiogen\u00e8si (g\u00e8nesi de vasos sanguinis necessaris per la nutrici\u00f3 i l\u2019expansi\u00f3 de les c\u00e8l\u00b7lules tumorals) indu\u00efda per TGF-beta. \u201cEs tracta d\u2019inhibir el seu receptor ALK 1 i aconseguir un efecte antiangiog\u00e8nic que faci que les c\u00e8l\u00b7lules tumorals no puguin cr\u00e9ixer ni migrar\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"
L\u2019estudi dels mecanismes moleculars que regulen les vies de senyalitzaci\u00f3 del Factor de Creixement Transformant (TGF-beta) \u00e9s el camp d\u2019actuaci\u00f3 de Peter Ten Djike i el grup de recerca que dirigeix a la Universitat de Leiden, a Holanda. Ten Djike ha explicat els seus \u00faltims aven\u00e7os en una confer\u00e8ncia dins el cicle de seminaris IDIBELL […]<\/p>\n","protected":false},"author":6,"featured_media":23040,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-12 13:53:48","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9541"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9541"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9541\/revisions"}],"predecessor-version":[{"id":23045,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9541\/revisions\/23045"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/23040"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}