{"id":9519,"date":"2012-04-26T00:00:00","date_gmt":"2012-04-25T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2012\/04\/26\/nuria-malats-el-repte-de-lepidemiologia-es-com-analitzar-totes-les-dades-referents-a-una-malaltia\/"},"modified":"2022-09-02T16:08:32","modified_gmt":"2022-09-02T14:08:32","slug":"nuria-malats-el-repte-de-lepidemiologia-es-com-analitzar-totes-les-dades-referents-a-una-malaltia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2012\/04\/nuria-malats-el-repte-de-lepidemiologia-es-com-analitzar-totes-les-dades-referents-a-una-malaltia\/","title":{"rendered":"N\u00faria Malats: \u201cel repte de l\u2019epidemiologia \u00e9s com analitzar totes les dades referents a una malaltia\u201d"},"content":{"rendered":"<p class=\"textonormal\"><span class=\"textenivell4\">La integraci\u00f3 de diversos nivells d\u2019informaci\u00f3 associats a una malaltia, com els aspectes relacionats amb l\u2019exposici\u00f3 ambiental, l\u2019epigen\u00e8tica, la gen\u00e8tica, la gen\u00f2mica, la metabol\u00f2mica, la transcript\u00f2mica o la prote\u00f2mica requereix el desenvolupament de dissenys innovadors aix\u00ed com de noves eines metodol\u00f2giques. La cap del grup de recerca d\u2019Epidemiologia Gen\u00e8tica i Molecular del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), N\u00faria Malats, va oferir una confer\u00e8ncia sobre els reptes de l\u2019epidemiologia el 20 d\u2019abril a la sala Pau Viladiu de l\u2019Hospital Duran i Reynals (ICO), dins del cicle de seminaris IDIBELL. La xerrada duia un t\u00edtol evocador: \u201cepidemiology and\u00a0<em>omics<\/em>: will the leaves hide the forest?\u201d (<em>epidemiologia i\u00a0<\/em>omiques<em>: les fulles amagaran el bosc?<\/em>).<\/span><\/p>\n<p class=\"textonormal\"><span class=\"textenivell4\">La doctora Malats estudia els factors que incideixen en l\u2019aparici\u00f3 i la progressi\u00f3 de diverses malalties, sobretot c\u00e0ncers de bufeta, p\u00e0ncrees i mama. Els factors ambientals tenen un pes molt important en aquestes patologies, per\u00f2 tamb\u00e9 la predisposici\u00f3 gen\u00e8tica dels pacients. Durant la seva confer\u00e8ncia, N\u00faria Malats es va centrar sobretot en el c\u00e0ncer de bufeta, que t\u00e9 una incid\u00e8ncia for\u00e7a elevada entre la poblaci\u00f3 espanyola. La investigadora va fer refer\u00e8ncia a l\u2019estudi EPICURO, en qu\u00e8 participa el seu grup, que ha perm\u00e8s recollir dades de m\u00e9s de 1.300 casos de 18 hospitals espanyols. Es tracta d\u2019un estudi prospectiu que ha perm\u00e8s realitzar un seguiment dels pacients durant m\u00e9s de deu anys, i s\u2019han recollit moltes dades fent servir diferents t\u00e8cniques, que la investigadora resumeix amb el terme \u201comiques\u201d (gen\u00f2mica, metabol\u00f2mica, transcript\u00f2mica, etc.).<\/span><\/p>\n<p class=\"textonormal\"><strong><span class=\"textenivell4\">Fulles que amaguen el bosc<\/span><\/strong><\/p>\n<p class=\"textonormal\"><span class=\"textenivell4\">Durant els darrers anys, han aparegut noves tecnologies i nous abordatges de les malalties que plantegen nous reptes a l\u2019epidemiologia. La doctora Malats en cita diversos, com la identificaci\u00f3 d\u2019una gran quantitat d\u2019alteracions gen\u00e8tiques a trav\u00e9s de les noves tecnologies de seq\u00fcenciaci\u00f3, el pas d\u2019un abordatge dirigit per hip\u00f2tesis a un altre de car\u00e0cter exploratori o agn\u00f2stic, la nova concepci\u00f3 de la malaltia com a proc\u00e9s din\u00e0mic, la necessitat de considerar resultats intermedis com l\u2019expressi\u00f3 gen\u00e8tica o la funci\u00f3 de les prote\u00efnes i, al mateix temps, l\u2019exig\u00e8ncia de considerar fen\u00f2mens globals per comprendre com responen els individus davant d\u2019unes determinades condicions ambientals. Tots aquests elements poden arribar a ser \u201cfulles que ens acabin amagant el bosc\u201d.<\/span><\/p>\n<p class=\"textonormal\"><span class=\"textenivell4\">Durant el seminari, N\u00faria Malats va proposar incorporar tots aquests elements per poder elaborar un nou model que integri l\u2019epidemiologia i les \u201c\u00f2miques\u201d. En aquest model, el terme \u201cexposici\u00f3\u201d se substitueix per \u201cexposoma\u201d, que s\u2019avalua mitjan\u00e7ant t\u00e8cniques de metabol\u00f2mica i epigen\u00f2mica. La \u201cmalaltia\u201d rep el nom de \u201cfenomen\u201d, i \u00e9s avaluat mitjan\u00e7ant t\u00e8cniques de gen\u00f2mica, transcript\u00f2mica i prote\u00f2mica.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La integraci\u00f3 de diversos nivells d\u2019informaci\u00f3 associats a una malaltia, com els aspectes relacionats amb l\u2019exposici\u00f3 ambiental, l\u2019epigen\u00e8tica, la gen\u00e8tica, la gen\u00f2mica, la metabol\u00f2mica, la transcript\u00f2mica o la prote\u00f2mica requereix el desenvolupament de dissenys innovadors aix\u00ed com de noves eines metodol\u00f2giques. La cap del grup de recerca d\u2019Epidemiologia Gen\u00e8tica i Molecular del Centro Nacional de [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":22115,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9519","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2025-03-02 13:31:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9519"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9519\/revisions"}],"predecessor-version":[{"id":22116,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9519\/revisions\/22116"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/22115"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}