La revista Nature ha publicat en el primer n\u00famero de maig un comentari del director del grup de recerca de Metabolisme i C\u00e0ncer de l’IDIBELL, George Thomas, i de l’investigador del mateix grup Antonio Gentilella. Els investigadors parlen sobre dos estudis publicats al mateix n\u00famero de la revista, sobre la prote\u00efna quinasa mTOR, un regulador clau per a la s\u00edntesi de les prote\u00efnes. La quinasa mTOR regula la transici\u00f3 de diverses prote\u00efnes que promouen la progressi\u00f3 del cicle cel\u00b7lular. Un funcionament an\u00f2mal de mTOR est\u00e0 relacionat amb nombroses malalties, particularment el c\u00e0ncer.<\/p>\n
Els dos treballs comentats pels investigadors de l’IDIBELL es refereixen a estudis realitzats amb una tecnologia novedosa de translaci\u00f3 activa d’ARN missatger, seguit de la inhibici\u00f3 de mTOR a trav\u00e9s de dos f\u00e0rmacs, que ha perm\u00e8s obtenir una nova visi\u00f3 de la funci\u00f3 d’aquesta prote\u00efna clau. En l’article, titulat “the director’s cut” (la versi\u00f3 del director), Thomas i Gentilella destaquen que els resultats dels estudis comentats “suggereixen l’exist\u00e8ncia de un codi <\/em>definit de mTOR que podria modular els efectes d’aquesta prote\u00efna segons diferents circumst\u00e0ncies cel\u00b7lulars”.<\/p>\n Els dos investigadors s’han incorporat recentment a l’IDIBELL, procedents de l’Institut de Malalties Metab\u00f2liques de la Universitat de Cincinnati, i formen part del nou grup de Metabolisme i C\u00e0ncer al centre de recerca de Bellvitge.<\/p>\n <\/p>\n Refer\u00e8ncia de l’article<\/strong><\/p>\n Gentilella A, Thomas G. Cancer biology: The director’s cut. Nature. 2012 May 2;485(7396):50-1. doi: 10.1038\/485050a.<\/p>\n","protected":false},"excerpt":{"rendered":" La revista Nature ha publicat en el primer n\u00famero de maig un comentari del director del grup de recerca de Metabolisme i C\u00e0ncer de l’IDIBELL, George Thomas, i de l’investigador del mateix grup Antonio Gentilella. Els investigadors parlen sobre dos estudis publicats al mateix n\u00famero de la revista, sobre la prote\u00efna quinasa mTOR, un regulador […]<\/p>\n","protected":false},"author":6,"featured_media":22105,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,408],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 03:34:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9515"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9515"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9515\/revisions"}],"predecessor-version":[{"id":22106,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9515\/revisions\/22106"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/22105"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}