{"id":9506,"date":"2012-06-05T00:00:00","date_gmt":"2012-06-04T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2012\/06\/05\/identificat-un-antioncogen-dins-dun-oncogen\/"},"modified":"2022-06-15T12:23:37","modified_gmt":"2022-06-15T10:23:37","slug":"identificat-un-antioncogen-dins-dun-oncogen","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2012\/06\/identificat-un-antioncogen-dins-dun-oncogen\/","title":{"rendered":"Identificat un antioncog\u00e8n dins d&#8217;un oncog\u00e8n"},"content":{"rendered":"<p>Un punt en com\u00fa en tots els tumors humans \u00e9s que produeixen una activaci\u00f3 dels oncogens, gens causants de c\u00e0ncer, i provoquen una p\u00e8rdua de la funci\u00f3 dels gens protectors, anomenats antioncogens o gens supressors tumorals. Normalment ambdues categories de gens, procancerosos i anticancerosos, es troben en regions diferents dels nostres cromosomes. Un estudi coordinat per Manel Esteller, director del programa d&#8217;epigen\u00e8tica i biologia del c\u00e0ncer de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), professor de gen\u00e8tica de la Universitat de Barcelona i investigador ICREA, ha descobert l&#8217;exist\u00e8ncia d&#8217;una mol\u00e8cula antitumoral que s&#8217;origina dins d&#8217;un oncog\u00e8n. La troballa es publica aquesta setmana a la revista cient\u00edfica <em>Nature Structural &amp; Molecular Biology<\/em>.<\/p>\n<p>L\u2019antioncog\u00e8n identificat \u00e9s un \u00e0cid ribonucleic llarg no codificant (lncRNA), \u00e9s a dir, una mol\u00e8cula que no produeix prote\u00efnes ella mateixa sin\u00f3 que s&#8217;encarrega de regular l&#8217;expressi\u00f3 d&#8217;altres prote\u00efnes. En concret, la mol\u00e8cula identificada es fabrica dins d&#8217;un gen que causa c\u00e0ncer (SMYD3) pel que la seva funci\u00f3 en c\u00e8l\u00b7lules sanes consisteix en inhibir l&#8217;acci\u00f3 pro-cancerosa de l&#8217;oncog\u00e8n.<br \/>\nSi s&#8217;introdueix aquest fragment d&#8217;\u00e0cid ribonucleic a c\u00e8l\u00b7lules canceroses que creixen al laboratori o a tumors humans implantats en animals de recerca \u00e9s capa\u00e7 de bloquejar el creixement del c\u00e0ncer. &#8220;Creiem que aquest descobriment ser\u00e0 el punt de partida per trobar molts altres oncogens i antioncogens que cohabiten en regions del nostre genoma i que, quan la seva conviv\u00e8ncia es deteriora, contribueixen al desenvolupament de tumors humans&#8221;, comenta el Dr Esteller.<\/p>\n<p><strong>Refer\u00e8ncia de l&#8217;article:<\/strong><br \/>\nIntronic RNAs mediate EZH2 regulation of epigenetic targets. S\u00f2nia Guil*, Marta Soler*, Anna Portela*, Jordi Carr\u00e8re*, Elena Fonalleras*, Antonio G\u00f3mez*, Alberto Villanueva* and <strong><span style=\"text-decoration: underline;\">Manel Esteller*<\/span><\/strong>. <strong><em>Nature Structural &amp; Molecular Biology<\/em><\/strong> <strong><em>(NSMB)<\/em><\/strong>, Early Edition, May 21, 2012.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un punt en com\u00fa en tots els tumors humans \u00e9s que produeixen una activaci\u00f3 dels oncogens, gens causants de c\u00e0ncer, i provoquen una p\u00e8rdua de la funci\u00f3 dels gens protectors, anomenats antioncogens o gens supressors tumorals. Normalment ambdues categories de gens, procancerosos i anticancerosos, es troben en regions diferents dels nostres cromosomes. Un estudi coordinat [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":21010,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,376,447,452,346],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 12:11:49","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9506"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9506"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9506\/revisions"}],"predecessor-version":[{"id":21661,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9506\/revisions\/21661"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21010"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}