Un estudi internacional coordinat per Manel Esteller comprova com les marques epigen\u00e8tiques es van degradant al llarg del temps. Com les lesions epigen\u00e8tiques s\u00f3n reversibles es podrien arribar a desenvolupar f\u00e0rmacs que augmentin el temps de vida. Qu\u00e8 passa en les nostres c\u00e8l\u00b7lules despr\u00e9s de cent anys de vida? En qu\u00e8 es diferencia a nivell molecular un nad\u00f3 i un centenari? Es tracta de canvis graduals o sobtats? \u00c9s possible revertir el proc\u00e9s d’envelliment? Quines s\u00f3n les claus moleculars de la longevitat? Aquestes q\u00fcestions centrals en biologia, fisiologia i medicina humana han estat focus d’estudi d’investigadors durant d\u00e8cades.<\/p>\n
La revista internacional Proceedings of the National Academy of Sciences<\/em> (PNAS) publica una investigaci\u00f3 de col\u00b7laboraci\u00f3 internacional dirigida per Manel Esteller, director del programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), professor de gen\u00e8tica de la Universitat de Barcelona i investigador ICREA, que proporciona una pista essencial en aquest camp: l’epigenoma dels nadons i dels centenaris \u00e9s diferent.<\/p>\n Mentre que el genoma de totes les c\u00e8l\u00b7lules del cos hum\u00e0, amb independ\u00e8ncia del seu aspecte i funci\u00f3, \u00e9s id\u00e8ntic, els senyals qu\u00edmics que el regulen, coneguts com a marques epigen\u00e8tiques, s\u00f3n especifiques de cada teixit hum\u00e0 i de cada \u00f2rgan. \u00c9s a dir, que tots els nostres components tenen el mateix abecedari (genoma), per\u00f2 l’ortografia (epigenoma) \u00e9s diferent en cada part de la nostra anatomia. El resultat sorprenent del treball del grup del Dr Esteller \u00e9s que, fins i tot per a un mateix teixit o \u00f2rgan, l’epigenoma varia en funci\u00f3 de l’edat de la persona.<\/p>\n En l’estudi publicat a PNAS s’han seq\u00fcenciat totalment els epigenomes de les c\u00e8l\u00b7lules blanques de la sang d’un nad\u00f3, un individu d’edat interm\u00e8dia i una persona de 103 anys. Els resultats demostren que el centenari presenta un epigenoma distorsionat que ha perdut molts interruptors (grup qu\u00edmic metil), encarregats d’apagar l’expressi\u00f3 de gens inapropiats i, en canvi, s’apaga l’interruptor d’alguns gens protectors.<\/p>\n “Estenent els resultats a un grup nombr\u00f3s de nounats, individus situats en el punt mig i nonagenaris o centenaris ens adonem que es tracta d’un proc\u00e9s progressiu en el que cada dia que passa l’epigenoma es va tor\u00e7ant”, afirma l’investigador. No obstant aix\u00f2, el doctor Esteller destaca que “les lesions epigen\u00e8tiques, a difer\u00e8ncia de les gen\u00e8tiques, s\u00f3n reversibles i, per tant, la modificaci\u00f3 dels patrons de la metilaci\u00f3 de l’ADN per canvis diet\u00e8tics o per l’\u00fas de f\u00e0rmacs podria induir un augment del temps de vida”.<\/p>\n <\/p>\n Refer\u00e8ncia de l’article:<\/strong><\/p>\n Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Deu J, Sanchez-Mut JV, Setien F, Carmona FJ, Pucaf AA Sayols S, Pujana MA, Serra-Musach J, Iglesias-Plata I, Formiga F, Fernandez AF, Fraga MF, Heath S, Val\u00e8ncia A, Gut IG, Wang J, Esteller M. The DISTINCT DNA Methylomes of Newborns and Centenarians. Proc Natl Acad Sci USA, DOI10.1073, 2012. Un estudi internacional coordinat per Manel Esteller comprova com les marques epigen\u00e8tiques es van degradant al llarg del temps. Com les lesions epigen\u00e8tiques s\u00f3n reversibles es podrien arribar a desenvolupar f\u00e0rmacs que augmentin el temps de vida. Qu\u00e8 passa en les nostres c\u00e8l\u00b7lules despr\u00e9s de cent anys de vida? En qu\u00e8 es diferencia a nivell […]<\/p>\n","protected":false},"author":6,"featured_media":21641,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[427],"tags":[],"class_list":["post-9502","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-malalties-sistemiques-i-envelliment"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 23:09:09","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9502"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9502\/revisions"}],"predecessor-version":[{"id":21642,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9502\/revisions\/21642"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21641"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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