La inhibici\u00f3 de la prote\u00efna DREAM podria actuar contra la malaltia de Huntington, segons Jos\u00e9 Ram\u00f3n Naranjo, investigador del Departament de Biologia Cel\u00b7lular i Molecular, del Centre Nacional de Biotecnologia (CNB-CSIC). El Dr. Naranjo va participar en un seminari IDIBELL el 6 de juliol a l\u2019Hospital Duran i Reynals.<\/p>\n
DREAM, tamb\u00e9 coneguda com KCNIP o calsenilina, \u00e9s una prote\u00efna codificada en humans pel gen KCNIP3 que \u00e9s un repressor transcripcional en el nucli i regula el tr\u00e0nsit de potassi (K+) i de calci (Ca2+) interactuant amb canals espec\u00edfics per a aquests ions. “Preparem ratolins transg\u00e8nics que sobreexpressen una prote\u00efna DREAM mutant que \u00e9s constitutivament activa, daDREAM”, va explicar l’investigador, que resumia a continuaci\u00f3 el resultat de les seves investigacions: “l’an\u00e0lisi del transcriptoma d’aquests ratolins va mostrar que DREAM regula l’expressi\u00f3 g\u00e8nica dependent d’activitat en l’hipocamp i per tant \u00e9s essencial en els processos de mem\u00f2ria i aprenentatge”, va comentar el Dr. Naranjo.<\/p>\n
Com va explicar l’investigador, DREAM regula directament l’expressi\u00f3 basal i indu\u00efda de molts gens d’inducci\u00f3 primerenca que al seu torn regulen altres gens. \u00c9s a dir, la prote\u00efna DREAM regula l’activaci\u00f3 i la desactivaci\u00f3 de diverses cascades transcripcionals dependents de l’activitat de les neurones que controlen la plasticitat sin\u00e0ptica, l’aprenentatge i la mem\u00f2ria. DREAM regula tamb\u00e9 les expressions g\u00e8niques dependent de calci i l’homeostasi, de manera que sembla tenir un paper important en la malaltia de Huntington, una greu afectaci\u00f3 neurodegenerativa que afecta persones de mitjana edat.<\/p>\n
<\/p>\n
DREAM i la malaltia de Huntington<\/strong><\/p>\n La malaltia de Huntington \u00e9s heredit\u00e0ria i es produeix per mutaci\u00f3 d’una prote\u00efna anomenada huntingtina. La huntingtina mutant (mHtt) modifica l’expressi\u00f3 g\u00e8nica de manera molt extensa i, en particular, t\u00e9 un efecte sobre els gens relacionats amb l’home\u00f2stasi del Ca2+. Aquest efecte s’ha vist en ratolins i en humans.<\/p>\n “Intentem veure si l’expressi\u00f3 end\u00f2gena de DREAM est\u00e0 modificada en un model mur\u00ed de la malaltia de Huntington”, va explicar l’investigador. “Hem trobat una disminuci\u00f3 primerenca en l’expressi\u00f3 de DREAM en els teixits perif\u00e8rics d’aquests ratolins. A m\u00e9s, diverses evid\u00e8ncies gen\u00e8tiques indiquen que DREAM regula l’aparici\u00f3 i progressi\u00f3 de la malaltia de Huntington en models animals de la malaltia, va continuar Naranjo. Pel que la inhibici\u00f3 farmacol\u00f2gica de DREAM pot representar una nova diana per al tractament d’aquesta malaltia neurol\u00f2gica.<\/p>\n Nova estrat\u00e8gia terap\u00e8utica<\/strong><\/p>\n El bloqueig de l’activitat de DREAM podria representar una nova estrat\u00e8gia terap\u00e8utica en la malaltia de Huntington. Aquests resultats suggereixen que el tractament amb inhibidors de DREAM podria millorar la malaltia de Huntington.<\/p>\n","protected":false},"excerpt":{"rendered":" La inhibici\u00f3 de la prote\u00efna DREAM podria actuar contra la malaltia de Huntington, segons Jos\u00e9 Ram\u00f3n Naranjo, investigador del Departament de Biologia Cel\u00b7lular i Molecular, del Centre Nacional de Biotecnologia (CNB-CSIC). El Dr. Naranjo va participar en un seminari IDIBELL el 6 de juliol a l\u2019Hospital Duran i Reynals. DREAM, tamb\u00e9 coneguda com KCNIP o […]<\/p>\n","protected":false},"author":6,"featured_media":21275,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[491,493],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-14 03:35:38","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9478"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9478"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9478\/revisions"}],"predecessor-version":[{"id":21276,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9478\/revisions\/21276"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21275"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9478"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9478"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9478"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}