L’equip dirigit per l’investigador Manel Esteller, director del Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), professor de gen\u00e8tica de la Universitat de Barcelona i Investigador ICREA, ha posat al dia les troballes m\u00e9s recents en epigen\u00e8tica aplicada en un treball de revisi\u00f3 publicat per la revista cient\u00edfica Nature Reviews Genetics.<\/p>\n
Cada vegada hi ha m\u00e9s necessitat de disposar de millors marcadors biol\u00f2gics que permetin detectar de forma preco\u00e7 les malalties humanes, especialment el c\u00e0ncer. Els marcadors permeten millorar la prevenci\u00f3 prim\u00e0ria, el diagn\u00f2stic i el pron\u00f2stic de les malalties. A m\u00e9s, fa possible predir quins tractaments poden ser m\u00e9s efica\u00e7os segons les caracter\u00edstiques del pacient, el que es coneix amb el nom de medicina personalitzada.<\/p>\n
Les proves gen\u00e8tiques complement\u00e0ries als m\u00e8todes tradicionals han estat \u00fatils per millorar l’abordatge de diverses malalties, per\u00f2 en els \u00faltims deu anys l’epigen\u00e8tica ha emergit tamb\u00e9 amb for\u00e7a per ajudar a solucionar aquestes situacions cl\u00edniques, segons destaca l’article. L’epigen\u00e8tica \u00e9s la disciplina que estudia les modificacions qu\u00edmiques en el nostre material gen\u00e8tic i en les prote\u00efnes reguladores del mateix. La marca epigen\u00e8tica m\u00e9s reconeguda \u00e9s l’addici\u00f3 d’un grup metil a l’ADN.<\/p>\n
L’estudi destaca que aquesta \u00faltima d\u00e8cada s’ha vist com dues proves basades en la metilaci\u00f3 de dos gens, MGMT i GSTP1, han resultat de vital import\u00e0ncia en la predicci\u00f3 de tumors de cervell sensibles al f\u00e0rmac temozolamida i en la distinci\u00f3 de c\u00e0ncer de pr\u00f2stata front al creixement benigne, respectivament. El doctor Esteller puntualitza que “el m\u00e9s excitant actualment \u00e9s que nous biomarcadors epigen\u00e8tics estan sent identificats per predir el comportament i els punts febles dels tumors a un ritme trepidant”. En aquest sentit, el coordinador de l’estudi cita la recent identificaci\u00f3 d’alteracions en gens epigen\u00e8tics predictors de resposta a f\u00e0rmacs de nova generaci\u00f3 en leuc\u00e8mies i el fet que l’obtenci\u00f3 d’una “foto” del patr\u00f3 de metilaci\u00f3 d’ADN pugui desemmascarar tumors de origen desconegut que fins ara tenien molt mal pron\u00f2stic.<\/p>\n
Refer\u00e8ncia de l’article<\/strong> L’equip dirigit per l’investigador Manel Esteller, director del Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), professor de gen\u00e8tica de la Universitat de Barcelona i Investigador ICREA, ha posat al dia les troballes m\u00e9s recents en epigen\u00e8tica aplicada en un treball de revisi\u00f3 publicat per la revista cient\u00edfica Nature Reviews […]<\/p>\n","protected":false},"author":6,"featured_media":21258,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[376],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 01:59:16","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9470"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9470"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9470\/revisions"}],"predecessor-version":[{"id":21259,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9470\/revisions\/21259"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21258"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nHeyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nature Reviews Genetics, September 4, 2012.<\/p>\n","protected":false},"excerpt":{"rendered":"