Investigadors de l\u2019IDIBELL i de l\u2019ICO han participat en un estudi internacional sobre la transcripci\u00f3 de gens mitjan\u00e7ant fosforilaci\u00f3 de substrats espec\u00edfics relacionat amb la progressi\u00f3 del c\u00e0ncer i la met\u00e0stasi. Aquesta investigaci\u00f3 ha estat publicada aquesta setmana a la revista cient\u00edfica Cell Reports.<\/p>\n
L\u2019estudi, liderat per investigadors de l\u2019Institut Municipal d\u2019Investigacions M\u00e8diques (IMIM) i en qu\u00e8 han participat els investigadors Alberto Villanueva i Mar\u00eda Mart\u00ednez, del grup de recerca de Qu\u00edmioresist\u00e8ncia i Factors Predictors de Resposta Tumoral i Medi Ambient Estromal de l\u2019IDIBELL i de l\u2019ICO, ha determinat la funci\u00f3 que t\u00e9 una nova variant de l\u2019enzim IKKalpha (IKK\u03b1) en la activaci\u00f3 d\u2019alguns dels gens involucrats en la progressi\u00f3 tumoral del c\u00e0ncer colorectal.<\/p>\n
El grup de recerca, per tal d\u2019aprofundir en el coneixement de la mec\u00e0nica entre la g\u00e8nesi tumoral i l’activitat d\u2019IKK\u03b1, va analitzar 288 mostres humanes de c\u00e0ncer de c\u00f2lon i va trobar una associaci\u00f3 significativa entre la pres\u00e8ncia d\u2019IKK nuclear i malignitat. Es va demostrar que l\u2019IKK\u03b1 nuclear regula la transcripci\u00f3 de gens mitjan\u00e7ant la fosforilaci\u00f3 de substrats espec\u00edfics, la qual cosa es relaciona amb la progressi\u00f3 del c\u00e0ncer i la met\u00e0stasi. \u00c9s important destacar que el nucli de les c\u00e8l\u00b7lules tumorals cont\u00e9 una isoforma activa d\u2019IKK\u03b1 amb un pes molecular de 45kDa, coneguda como P45-IKK\u03b1. En la majoria de mostres humanes de c\u00e0ncer de colon es va identificar la pres\u00e8ncia de P45-IKK\u03b1. Es va demostrar que el bloqueig espec\u00edfic d\u2019aquesta nova forma d\u2019IKK\u03b1 evita el creixement de les c\u00e8l\u00b7lules d\u2019aquest tipus de c\u00e0ncer. Els resultats podrien significar un avan\u00e7ament pel disseny de nous f\u00e0rmacs per inhibir aquest enzim de forma efectiva i ser menys t\u00f2xics per la resta de c\u00e8l\u00b7lules de l\u2019organisme.<\/p>\n
<\/p>\n
<\/p>\n
Refer\u00e8ncia de l’article<\/strong><\/p>\n A Truncated Form of IKK\u03b1 Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer. Pol Margalef, Vanessa Fern\u00e1ndez-Majada, Alberto Villanueva, Ricard Garcia-Carbonell, Mar Iglesias, Laura L\u00f3pez, Mar\u00eda Mart\u00ednez-Iniesta, Jordi Vill\u00e0-Freixa, Mari Carmen Mulero, Montserrat Andreu, Ferran Torres, Marty W. Mayo, Anna Bigas, Lluis Espinosa. Cell Reports 2, 1-15, October 25, 2012.<\/p>\n","protected":false},"excerpt":{"rendered":" Investigadors de l\u2019IDIBELL i de l\u2019ICO han participat en un estudi internacional sobre la transcripci\u00f3 de gens mitjan\u00e7ant fosforilaci\u00f3 de substrats espec\u00edfics relacionat amb la progressi\u00f3 del c\u00e0ncer i la met\u00e0stasi. Aquesta investigaci\u00f3 ha estat publicada aquesta setmana a la revista cient\u00edfica Cell Reports. L\u2019estudi, liderat per investigadors de l\u2019Institut Municipal d\u2019Investigacions M\u00e8diques (IMIM) i […]<\/p>\n","protected":false},"author":6,"featured_media":21010,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[332,447,452,346],"tags":[],"class_list":["post-9459","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-procure","category-quimioresistencia-tumoral-i-estromal"],"publishpress_future_action":{"enabled":false,"date":"2025-01-03 05:01:50","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9459"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9459\/revisions"}],"predecessor-version":[{"id":21011,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9459\/revisions\/21011"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21010"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}