L\u2019oncog\u00e8n MED12 \u00e9s b\u00e0sic en el control de resposta a nous f\u00e0rmacs oncol\u00f2gics, segons un estudi publicat a Cell i realitzat per investigadors de l’IDIBELL i l’ICO en col\u00b7laboraci\u00f3 amb investigadors de l’Institut Holand\u00e8s del C\u00e0ncer (NKI), a Amsterdam.<\/p>\n
Aquesta recerca, publicada a Cell, ha demostrat que l’oncog\u00e8n MED12 t\u00e9 un paper clau en el control de la resposta a diferents f\u00e0rmacs oncol\u00f2gics. Per desenvolupar l’estudi, els investigadors van emprar un model precl\u00ednic de pulm\u00f3, amb translocaci\u00f3 d\u2019ALK, molt sensible a crizotinib. Aquest f\u00e0rmac \u00e9s un inhibidor d\u2019ALK selectiu per a la prote\u00efna de fusi\u00f3 generada en produir-se aquesta translocaci\u00f3.<\/p>\n
La investigaci\u00f3 ha estat coordinada pel responsable cl\u00ednic i d’investigaci\u00f3 de c\u00e0ncer de c\u00f2lon de l’ICO-Hospitalet i investigador del grup de C\u00e0ncer Colorectal de l’IDIBELL, Ramon Salazar, que es va plantejar com identificar mecanismes de resist\u00e8ncia a critozinib. Per aix\u00f2 va col\u00b7laborar amb un grup de recerca de Ren\u00e9 Bernards, de l’Institut Holand\u00e8s del C\u00e0ncer (NKI), expert en interpretar els mecanismes de resist\u00e8ncia per poder fer hip\u00f2tesis i traslladar-les a assajos cl\u00ednics de combinaci\u00f3 de f\u00e0rmacs.<\/p>\n
En la investigaci\u00f3 es va confirmar un mecanisme d’acci\u00f3 comuna de resist\u00e8ncia a m\u00faltiples f\u00e0rmacs inhibidors de diverses vies que acaben en ERK (quinasa regulada per senyal extracel\u00b7lular). En els experiments d\u2019immunoprecipitaci\u00f3 conjunta es va confirmar una acci\u00f3 postranscripcional a nivell prote\u00f2mic i en el citoplasma. D’aquesta manera, quan es posa en contacte un model MED12KD augmenta l’expressi\u00f3 del receptor de TGF-beta a la membrana en disminuir la coprecipitaci\u00f3 del citoplasma, una via de resist\u00e8ncia molt coneguda de m\u00faltiples receptors.<\/p>\n","protected":false},"excerpt":{"rendered":"
L\u2019oncog\u00e8n MED12 \u00e9s b\u00e0sic en el control de resposta a nous f\u00e0rmacs oncol\u00f2gics, segons un estudi publicat a Cell i realitzat per investigadors de l’IDIBELL i l’ICO en col\u00b7laboraci\u00f3 amb investigadors de l’Institut Holand\u00e8s del C\u00e0ncer (NKI), a Amsterdam. Aquesta recerca, publicada a Cell, ha demostrat que l’oncog\u00e8n MED12 t\u00e9 un paper clau en el […]<\/p>\n","protected":false},"author":6,"featured_media":21004,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,375,447],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 11:54:41","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9458"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9458"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9458\/revisions"}],"predecessor-version":[{"id":21005,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9458\/revisions\/21005"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/21004"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}