El c\u00e0ncer de c\u00f2lon hereditari \u00e9s una malaltia que, amb el seguiment adequat, es pot prevenir amb \u00e8xit. La S\u00edndrome de Lynch, o c\u00e0ncer de c\u00f2lon hereditari no polip\u00f2sic, \u00e9s la seva forma heredit\u00e0ria m\u00e9s freq\u00fcent (entre l’1% i el 3% del total de casos). Una simple prova en el si del tumor en tots els pacients amb c\u00e0ncer de c\u00f2lon i recte \u00e9s millor que qualsevol recomanaci\u00f3 cl\u00ednica per identificar els casos de s\u00edndrome de Lynch, la forma heredit\u00e0ria m\u00e9s freq\u00fcent d’aquest tipus de c\u00e0ncer. Entre dos i tres parents de cada pacient diagnosticat es podrien beneficiar de programes preventius que eviten fins al 80% dels tumors de c\u00f2lon.<\/p>\n
L’investigador de l’IDIBELL i l’ICO V\u00edctor Moreno ha participat en un treball internacional dirigit per investigadors de l’Institut d’Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)<\/a>, l’Hospital Cl\u00ednic<\/a> i la Universitat de Barcelona<\/a>, \u200b\u200bque proposa realitzar un test espec\u00edfic al si del tumor a tots els pacients de c\u00e0ncer de c\u00f2lon i recte per identificar la s\u00edndrome de Lynch, que actualment no est\u00e0 contemplat en les recomanacions cl\u00edniques aplicades.<\/p>\n L’estudi, publicat al darrer n\u00famero del Journal of the American Medical Association<\/em> (JAMA), compara l’efectivitat de les dues estrat\u00e8gies de refer\u00e8ncia per al tractament del c\u00e0ncer de c\u00f2lon \u2013conegudes com guies cl\u00edniques de Bethesda i recomanacions de Jerusalem\u2013 amb l’aplicaci\u00f3 d’un test (immunohistoqu\u00edmica i\/o inestabilitat de microsat\u00e8l\u00b7lits) que identifiqui els pacients portadors de les mutacions relacionades amb la s\u00edndrome de Lynch.<\/p>\n Segons els autors, es tracta de la major mostra utilitzada mai per a l’estudi d’aquesta s\u00edndrome, ja que ha ajuntat m\u00e9s de 10.000 casos, amb mostres que procedeixen d\u2019EPICOLON (Espanya), Colom Cancer Family Registry (EUA, Canad\u00e0 i Austr\u00e0lia), Ohio State University (EUA) i Universitat de Helsinki (Finl\u00e0ndia).<\/p>\n La recerca, dirigida pel Dr. Antoni Castells, de l’IDIBAPS-Hospital Cl\u00ednic, ha demostrat que una part important dels portadors de la s\u00edndrome seguiran sense identificar fins que es realitzi de forma universal un test espec\u00edfic en el tumor en tots els pacients diagnosticats de c\u00e0ncer de c\u00f2lon i recte.<\/p>\n Millora del diagn\u00f2stic<\/strong><\/p>\n Els resultats van revelar que la versi\u00f3 revisada de les guies cl\u00edniques de Bethesda, que data de 2004, no va servir per detectar el 12% dels casos de la s\u00edndrome de Lynch. Aix\u00ed mateix, les recomanacions de Jerusalem, que recomanen fer els tests en tots els pacients menors de 70 anys, van ser insuficients en el 15% dels casos.<\/p>\n Trenta mil nous casos a l’any<\/strong><\/p>\n A Espanya es detecten uns 30.000 nous casos de c\u00e0ncer de c\u00f2lon i recte a l’any. Fins a 900 podrien ser deguts a la s\u00edndrome de Lynch, la major part dels quals no han estat identificats correctament. A m\u00e9s, per cada cas de s\u00edndrome de Lynch detectat es poden identificar dos o tres casos asimptom\u00e0tics en la fam\u00edlia, que entrarien en un programa de seguiment m\u00e9s exhaustiu que el que s’utilitza en la poblaci\u00f3 general.<\/p>\n Al voltant del 80% dels portadors de les mutacions desenvoluparan un c\u00e0ncer de c\u00f2lon o recte, i la gran majoria ho faran abans dels 70 anys. En aquests casos el programa de prevenci\u00f3 inclou una colonosc\u00f2pia cada any, una inversi\u00f3 que evita fins al 80% dels casos de c\u00e0ncer de c\u00f2lon causa d\u2019aquesta s\u00edndrome.<\/p>\n Refer\u00e8ncia bibliogr\u00e0fica:<\/strong> Moreira L, Balaguer F, Lindor N, de la Chapelle A, Hampel H, Aaltonen LA, Hopper JL, Le Marchand L, Gallinger S, Newcomb PA, Haile R, Thibodeau SN, Gunawardena S, Jenkins MA, Buchanan DD, Potter JD, Baron JA, Ahnen DJ, Moreno V, Andreu M, Ponz de Leon M, Rustgi AK, Castells A; EPICOLON Consortium. Identification of Lynch Syndrome among Patients with Colorectal Cancer. JAMA, 17 d’octubre de 2012.<\/p>\n Font: <\/strong> IDIBAPS \/ Agencia SINC<\/p>\n","protected":false},"excerpt":{"rendered":" El c\u00e0ncer de c\u00f2lon hereditari \u00e9s una malaltia que, amb el seguiment adequat, es pot prevenir amb \u00e8xit. La S\u00edndrome de Lynch, o c\u00e0ncer de c\u00f2lon hereditari no polip\u00f2sic, \u00e9s la seva forma heredit\u00e0ria m\u00e9s freq\u00fcent (entre l’1% i el 3% del total de casos). Una simple prova en el si del tumor en tots […]<\/p>\n","protected":false},"author":6,"featured_media":20914,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,375,447],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 19:47:35","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9445"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9445"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9445\/revisions"}],"predecessor-version":[{"id":20916,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9445\/revisions\/20916"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20914"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}