La confer\u00e8ncia “Search, validation and clinical translation of new therapeutic targets in Ewing sarcoma found by integrative genomic analyses” d’Enrique de \u00c1lava, investigador del Centre d’Investigaci\u00f3 del C\u00e0ncer (CIC), a l’Hospital de la Universidad de Salamanca i el Consell Superior d’Investigacions Cient\u00edfiques (CSIC), va tenir lloc el passat 9 de novembre a l’IDIBELL.<\/p>\n
“Per intentar traslladar a la investigaci\u00f3 cl\u00ednica, vull introduir la g\u00e8nesi d’aquest tumor en particular. Hi ha una heterogene\u00eftat morfol\u00f2gica en el sarcoma d’Ewing”, va iniciar la xerrada el Dr. de \u00c1lava. En el sarcoma d’Ewing (EWS), els investigadors utilitzen la gen\u00e8tica, aix\u00ed com an\u00e0lisis morfol\u00f2giques per al seu estudi. Hi ha un esdeveniment molecular clau, com la fusi\u00f3 de gens, mutacions o c\u00f2pia d’alteracions, que actuen sobre els or\u00edgens c\u00e8l\u00b7lulars, juntament amb mutacions addicionals. Hi ha alguns objectius EWS-FLI1 i alguns factors que afecten la seva activitat.<\/p>\n
“Per explicar els episodis d\u2019EWS, tenim mutacions o alteracions epigen\u00e8tiques, com la mutaci\u00f3 del p53 o p16\/p14ARF. Hem vist la import\u00e0ncia funcional del gen candidat Cdt2”, va dir l’investigador.<\/p>\n
En el sarcoma d’Ewing tamb\u00e9 \u00e9s molt importants el microambient i el sistema immunitari. Hi ha una jerarquia en el tumor cel\u00b7lular. Els investigadors necessiten una millor comprensi\u00f3 molecular en l’EWS i troben diferents problemes: no hi ha lesions preneopl\u00e0siques ni “teixit normal” hom\u00f2leg ni tampoc hi ha un model animal gen\u00e8ticament modificat disponible. Hi ha una disponibilitat de mostres intestinals i, encara existeixes massa marcadors, molts d’ells no s\u00f3n enzims. “EWS-FLI1 \u00e9s un bon objectiu”, va recon\u00e8ixer de \u00c1lava.<\/p>\n
“Podem utilitzar una combinaci\u00f3 sin\u00e8rgica de drogues: dues dianes terap\u00e8utiques en la Fase I-II dels assajos cl\u00ednics en pacients que no responen a GEIS21”, va concloure l’investigador.<\/p>\n","protected":false},"excerpt":{"rendered":"
La confer\u00e8ncia “Search, validation and clinical translation of new therapeutic targets in Ewing sarcoma found by integrative genomic analyses” d’Enrique de \u00c1lava, investigador del Centre d’Investigaci\u00f3 del C\u00e0ncer (CIC), a l’Hospital de la Universidad de Salamanca i el Consell Superior d’Investigacions Cient\u00edfiques (CSIC), va tenir lloc el passat 9 de novembre a l’IDIBELL. “Per intentar […]<\/p>\n","protected":false},"author":6,"featured_media":20764,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[491,493],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-08 15:00:38","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9425"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9425"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9425\/revisions"}],"predecessor-version":[{"id":20765,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9425\/revisions\/20765"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20764"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9425"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9425"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}