La confer\u00e8ncia \u201cBAF60c-MyoD complex poises chromatin for myogenic differentiation\u201d de la Dra. S\u00f2nia Forcales, investigadora de l\u2019Institut de Medicina Predictiva i Personalitzada del C\u00e0ncer (IMPPC), que va tenir lloc el passat 22 de novembre a la Sala d\u2019Actes de la Universitat de Barcelona (Campus Bellvitge) es va centrar en el paper de BAF60c en la diferenciaci\u00f3 muscular i la distr\u00f2fia muscular.<\/p>\n
La Dra. Forcales va parlar de les distr\u00f2fies musculars (DMD). Hi ha m\u00e9s de 30 tipus de DMD i no hi ha una cura, nom\u00e9s tractament amb finalitat pal\u00b7liativa. El proc\u00e9s de degeneraci\u00f3 \u00e9s insuficient per fer coincidir el ritme de la degeneraci\u00f3 a la DMD. \u201cNosaltres fem servir un sistema in vitro<\/em> per estudiar un possible proc\u00e9s de regeneraci\u00f3. Vol\u00edem comprendre els canvis epigen\u00e8tics que ocorren en l’expressi\u00f3 de gens per diferenciar o multiplicar-s’hi. Hi ha tres BAF espec\u00edfiques que codifiquen gens: a, b i c. Per\u00f2 el BAF60c \u00e9s el m\u00e9s abundant i t\u00e9 un paper essencial per a la diferenciaci\u00f3 miog\u00e8nica”, va dir l’investigadora.<\/p>\n Quin \u00e9s el paper de BAF60c per al transcriptosoma miog\u00e8nic?<\/strong><\/p>\n La regulaci\u00f3 a la baixa de BAF60c evita la uni\u00f3 d’un transcriptosoma miog\u00e8nic actiu. Tamb\u00e9 \u00e9s important per a qualsevol etapa del muntatge. \u201cHi ha diferents complexos en mioblasts i miotubs associades al BAF60c. Els nostres col\u00b7laboradors a la Xina varen trobar que BAF60c preferentment interactua amb l\u2019homod\u00edmer MyoD. BAF60c i MyoD interactua en bioblasts”, va dir Forcales.<\/p>\n","protected":false},"excerpt":{"rendered":" La confer\u00e8ncia \u201cBAF60c-MyoD complex poises chromatin for myogenic differentiation\u201d de la Dra. S\u00f2nia Forcales, investigadora de l\u2019Institut de Medicina Predictiva i Personalitzada del C\u00e0ncer (IMPPC), que va tenir lloc el passat 22 de novembre a la Sala d\u2019Actes de la Universitat de Barcelona (Campus Bellvitge) es va centrar en el paper de BAF60c en la […]<\/p>\n","protected":false},"author":6,"featured_media":20750,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,513,447],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 08:29:12","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9421"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=9421"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9421\/revisions"}],"predecessor-version":[{"id":20751,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/9421\/revisions\/20751"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20750"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=9421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=9421"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=9421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}