La ter\u00e0pia cel\u00b7lular cada cop tindr\u00e0 m\u00e9s pes en la recerca card\u00edaca, va dir Antoni Bay\u00e9s-Gen\u00eds al Seminari IDIBELL “Bioprosthesis for Cardiac repair”, que va tenir lloc a la Sala Pau Viladiu a l’Hospital Duran i Reynals-ICO, el passat 18 de gener. Bay\u00e9s-Gen\u00eds \u00e9s cap de servei de Cardiologia de l’Hospital Universitari Germans Trias i Pujol de Badalona i investigador de l’Institut d’Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol (IGTP).<\/p>\n
L’investigador va parlar sobre la hist\u00f2ria de l’infart de miocardi en els \u00faltims 100 anys. Despr\u00e9s es va centrar en la capacitat regenerativa del cor hum\u00e0 en els \u00faltims 10 anys. La ter\u00e0pia cel\u00b7lular \u00e9s la primera opci\u00f3 per tractar els pacients despr\u00e9s d’un infart de miocardi. “El tractament amb medul\u00b7la \u00f2ssia va tenir un gran impacte en els pacients d’infart agut de miocardi”, explica l’investigador.<\/p>\n
L’enginyeria de teixits card\u00edacs<\/strong><\/p>\n Quins passos cal seguir fins a l’aplicaci\u00f3 cl\u00ednica? \u00c9s necess\u00e0ria l’enginyeria de teixits per al m\u00fascul del cor. Els empelts d’enginyeria tissular s’adapten b\u00e9 i mantenen l’estructura del teixit de miocardi.<\/p>\n “Rob Langer, del MIT, est\u00e0 treballant en Nanowired 3-D, uns pegats card\u00edacs per regenerar el teixit de miocardi. Un altre enfocament diferent \u00e9s l’aproximaci\u00f3 de Doris Taylor sobre enginyeria de teixits per al m\u00fascul del cor, amb tractament enzim\u00e0tic, tant f\u00edsic com qu\u00edmic, la vascularitzaci\u00f3 i recelularizaci\u00f3n aut\u00f2loga de teixits. Utilitzant el mateix concepte, el grup de Karen Christman usen un cor per extreure totes les seves c\u00e8l\u00b7lules i construir-ne un de nou”, va dir Bay\u00e9s-Gen\u00eds.<\/p>\n “El meu grup obt\u00e9 teixit adip\u00f3s card\u00edac derivat de les c\u00e8l\u00b7lules progenitores”, va explicar l’investigador i va continuar: “Volem obtenir m\u00e9s c\u00e8l\u00b7lules vasculars del teixit gras que envolta el cor. Provoquem, en un model animal, un infart per analitzar la mida de la cicatriu”. L’investigador explica que per dur a terme els seus assajos cl\u00ednics necessitaven candidats CABG amb cicatriu cr\u00f2nica no revascularizable. “Utilitzem implants avan\u00e7ats i materials bioactius per als \u00f2rgans cr\u00edtics desenvolupats per la Universitat Polit\u00e8cnica de Val\u00e8ncia (UPV), entre altres entitats, i altres tecnologies desenvolupades per la Universitat Polit\u00e8cnica de Catalunya (UPC), sobre electro-estimulaci\u00f3 mec\u00e0nica”, va explicar l’investigador cardiovascular.<\/p>\n La propera generaci\u00f3 de materials que s’estan desenvolupant ser\u00e0 un pegat intel\u00b7ligent: una bio-membrana i un teixit card\u00edac. Els microel\u00e8ctrodes s’implanten al cor en un model porc\u00ed, el cor i sistema vascular del qual \u00e9s el m\u00e9s proper a l’hum\u00e0, i que “permet mesurar i monitoritzar la regeneraci\u00f3 in vivo<\/em>“, va dir Bay\u00e9s-Gen\u00eds.<\/p>\n “Queden encara moltes coses a fer i aprendre en la regeneraci\u00f3 de teixits card\u00edacs. El meu grup de recerca vol traduir els resultats de la recerca a la pr\u00e0ctica cl\u00ednica”, va concloure l’investigador.<\/p>\n","protected":false},"excerpt":{"rendered":" La ter\u00e0pia cel\u00b7lular cada cop tindr\u00e0 m\u00e9s pes en la recerca card\u00edaca, va dir Antoni Bay\u00e9s-Gen\u00eds al Seminari IDIBELL “Bioprosthesis for Cardiac repair”, que va tenir lloc a la Sala Pau Viladiu a l’Hospital Duran i Reynals-ICO, el passat 18 de gener. Bay\u00e9s-Gen\u00eds \u00e9s cap de servei de Cardiologia de l’Hospital Universitari Germans Trias i […]<\/p>\n","protected":false},"author":6,"featured_media":20708,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[491,493],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 06:33:19","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8605"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8605"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8605\/revisions"}],"predecessor-version":[{"id":20709,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8605\/revisions\/20709"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20708"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}