Despr\u00e9s d\u2019una llarga traject\u00f2ria de col\u00b7laboraci\u00f3 entre tres grups de recerca de la UB-IDIBELL, el CSIC i la UAB en la investigaci\u00f3 dels \u00e0cids nucleics d\u2019interfer\u00e8ncia (siRNA), han trobat la soluci\u00f3 a l\u2019hora d\u2019inhibir, entre altres, gens implicats en malalties inflamat\u00f2ries, com per exemple les relacionades amb l’acci\u00f3 del Factor de Necrosi Tumoral (TNF-alfa). Com a resultat d\u2019aquest projecte el 2010 van sol\u00b7licitar una patent que ha estat recentment llicenciada a la companyia Janus Developments S.L.<\/p>\n
Els resultats obtinguts fins ara fan preveure que, a llarg termini, aquests productes podrien ser \u00fatils en el tractament de patologies inflamat\u00f2ries com la Malaltia de Crohn, Colitis ulcerosa, asma, psoriasi i fins i tot alguns tipus de malalties oncol\u00f2giques. Donat que en aquestes malalties esmentades, el TNF-alfa promou l\u2019estat patol\u00f2gic, \u00e9s clar que la regulaci\u00f3 d\u2019aquest factor podria permetre una millora considerable en els pacients quan finalment es pugui aplicar, despr\u00e9s del desenvolupament cl\u00ednic.<\/p>\n
Els resultats de recerca patentats han estat obtinguts a partir de la investigaci\u00f3 conjunta dels grups de recerca de diferents universitats i centres. Per part del CSIC, ha participat el Grup de Qu\u00edmica d\u2019\u00c0cids Nucleics, liderat pel Dr. Ramon Eritja, de l\u2019Institut de Qu\u00edmica Avan\u00e7ada (IQAC); per part de la UB, ha participat el Grup de Nutrici\u00f3, Metabolisme i Ter\u00e0pia G\u00e8nica de l\u2019IDIBELL (Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge), liderat pel Dr. Jos\u00e9 Carlos Perales; i de la UAB ha participat el Grup d\u2019Investigaci\u00f3 en Inflamaci\u00f3 i Toler\u00e0ncia, liderat per la Dra. Ester Fern\u00e1ndez.<\/p>\n
Janus Developments S.L, empresa que t\u00e9 per objectiu acostar la recerca b\u00e0sica a la ind\u00fastria amb la finalitat que les invencions puguin arribar realment als usuaris finals, ha llicenciat aquesta patent amb l\u2019objectiu de continuar madurant el desenvolupament d\u2019aquesta potencial ter\u00e0pia per a poder iniciar estudis precl\u00ednics. En el futur, es preveu incorporar altres partners<\/em> al projecte per a poder finan\u00e7ar el seu desenvolupament cl\u00ednic complet.<\/p>\n La Fundaci\u00f3 Bosch i Gimpera com a centre de transfer\u00e8ncia de coneixement, tecnologia i innovaci\u00f3 de la UB ha portat les negociacions del grup de recerca de la UB amb l\u2019empresa Janus Developments.<\/p>\n","protected":false},"excerpt":{"rendered":" Despr\u00e9s d\u2019una llarga traject\u00f2ria de col\u00b7laboraci\u00f3 entre tres grups de recerca de la UB-IDIBELL, el CSIC i la UAB en la investigaci\u00f3 dels \u00e0cids nucleics d\u2019interfer\u00e8ncia (siRNA), han trobat la soluci\u00f3 a l\u2019hora d\u2019inhibir, entre altres, gens implicats en malalties inflamat\u00f2ries, com per exemple les relacionades amb l’acci\u00f3 del Factor de Necrosi Tumoral (TNF-alfa). Com […]<\/p>\n","protected":false},"author":6,"featured_media":20700,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[334,462,461],"tags":[],"class_list":["post-8602","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-translacional","category-nutricio-metabolisme-i-terapia-genica","category-p-de-diabetis-i-metabolisme"],"publishpress_future_action":{"enabled":false,"date":"2025-01-25 00:45:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8602","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8602"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8602\/revisions"}],"predecessor-version":[{"id":20702,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8602\/revisions\/20702"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20700"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8602"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8602"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}