{"id":8598,"date":"2013-02-05T00:00:00","date_gmt":"2013-02-04T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2013\/02\/05\/el-projecte-europeu-coltheres-classifica-el-cancer-colorectal-en-tres-subtipus\/"},"modified":"2022-02-23T12:55:08","modified_gmt":"2022-02-23T11:55:08","slug":"el-projecte-europeu-coltheres-classifica-el-cancer-colorectal-en-tres-subtipus","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2013\/02\/el-projecte-europeu-coltheres-classifica-el-cancer-colorectal-en-tres-subtipus\/","title":{"rendered":"El projecte europeu COLTHERES classifica el c\u00e0ncer colorectal en tres subtipus"},"content":{"rendered":"

Els investigadors del projecte europeu COLTHERES <\/span><\/a>han presentat en el Congr\u00e9s de l\u2019American Society of Clinical Oncology<\/span><\/a> Gastrointestinal Cancers, celebrat entre el 24 i el 26 de gener, els resultats preliminars del programa que t\u00e9 com a objectiu fomentar els assaigs cl\u00ednics de ter\u00e0pies personalitzades en c\u00e0ncer colorectal.<\/p>\n

Els investigadors del projecte COLTHERES han desenvolupat un nou sistema de classificaci\u00f3 que categoritza els tumors colorectals en tres subtipus completament diferents segons el seu patr\u00f3 d\u2019expressi\u00f3 gen\u00e8tica. L\u2019objectiu final \u00e9s utilitzar aquesta nova classificaci\u00f3 en la pressa de decisions terap\u00e8utiques.<\/p>\n

Josep Tabernero, director cl\u00ednic de l\u2019Institut d\u2019Oncologia de la Vall d\u2019Hebron<\/span><\/a>, ha estat l\u2019encarregat de presentar l\u2019estudi al congr\u00e9s de l\u2019ASCO GI. Tabernero ha explicat que aquesta categoritzaci\u00f3 \u201cpodria ser cl\u00ednicament rellevant, ja que els tumors difereixen en la seva biologia i en el seu desenvolupament en els pacients i, per tant requereixen diferents estrat\u00e8gies de tractament\u201d.<\/p>\n

Els pacients amb subtipus C s\u00f3n els de pitjor pron\u00f2stic i responen malament al tractament de quimioter\u00e0pia amb fluorouracil, mentre que els subtipus A i B tenen millors resultats.<\/p>\n

Qu\u00e8 \u00e9s COLTHERES?<\/p>\n

<\/strong> En el projecte COLTHERES participen hospitals i centres de recerca translacional de sis pa\u00efsos europeus i el seu objectiu final \u00e9s desenvolupar ter\u00e0pies personalitzades en c\u00e0ncer de c\u00f2lon. El consorci est\u00e0 integrat per unitats cl\u00edniques pioneres en test de biomarcadors en ter\u00e0pies personalitzades i grups de recerca translacional l\u00edders amb una traject\u00f2ria provada a l\u2019hora de desenvolupar diagn\u00f2stics per a ter\u00e0pies contra el c\u00e0ncer.<\/p>\n

El Programa d\u2019Epigen\u00e8tica i Biologia del C\u00e0ncer de l\u2019IDIBELL, liderat per Manel Esteller, forma part d\u2019aquest projecte que compta amb experts internacionals en els camps de la gen\u00e8tica funcional, l\u2019epigen\u00f2mica, la farmacogen\u00e8tica i l\u2019oncologia cl\u00ednica. L\u2019aportaci\u00f3 de l\u2019IDIBELL \u00e9s obtenir perfils epigen\u00f2mics dels pacients i dels models experimentals per trobar nous biomarcadors de pron\u00f2stic i de resist\u00e8ncia a f\u00e0rmacs en c\u00e0ncer colorectal.<\/p>\n","protected":false},"excerpt":{"rendered":"

Els investigadors del projecte europeu COLTHERES han presentat en el Congr\u00e9s de l\u2019American Society of Clinical Oncology Gastrointestinal Cancers, celebrat entre el 24 i el 26 de gener, els resultats preliminars del programa que t\u00e9 com a objectiu fomentar els assaigs cl\u00ednics de ter\u00e0pies personalitzades en c\u00e0ncer colorectal. Els investigadors del projecte COLTHERES han desenvolupat […]<\/p>\n","protected":false},"author":6,"featured_media":20654,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[376],"tags":[],"class_list":["post-8598","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-epigenetica-del-cancer"],"publishpress_future_action":{"enabled":false,"date":"2024-12-02 00:32:43","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8598"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8598\/revisions"}],"predecessor-version":[{"id":20655,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8598\/revisions\/20655"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/20654"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}